Andrea Nistri

TL;DR: Nicotinic ACh receptors can undergo desensitization, a reversible reduction in response during sustained agonist application, indicating that it might be important to control synaptic efficacy, responses to cholinergic agents, and certain nAChR-related disease states.

TL;DR: Findings indicate that glutamate-stimulated ATP release from astrocytes was most likely exocytotic and that after stimulation the fraction of quinacrine-loaded vesicles, spontaneously exhibiting directional mobility, disappeared.

TL;DR: A new form of selective, slow upregulation of nociceptive P2X3 receptors on trigeminal neurons by CGRP is demonstrated, which might contribute to pain sensitization and represents a model of neuronal plasticity in response to a migraine mediator.

TL;DR: Results show that in the rat spinal cord highly patterned motor output can occur despite block of inhibition, and Rhythmic bursts appear to result from large, synchronous synaptic events generated by a network modulated by 5-HT and highly sensitive to variations in efficacy of glutamatergic synaptic transmission.

TL;DR: The results suggest that bursting induced by strychnine and bicuculline apparently relied on distinct mechanisms for burst triggering and intraburst structure, which required a relatively smaller neuronal network that was confined to a ventral quadrant.