A
Andrea Wolf
Researcher at Research Institute of Molecular Pathology
Publications - 3
Citations - 824
Andrea Wolf is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Heterochromatin & Regulation of gene expression. The author has an hindex of 3, co-authored 3 publications receiving 794 citations.
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Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31
Louise Aagaard,Götz Laible,Philipp Selenko,Manfred Schmid,Rainer Dorn,Gunnar Schotta,Steffi Kuhfittig,Andrea Wolf,Angelika Lebersorger,Prim B. Singh,Gunter Reuter,Thomas Jenuwein +11 more
TL;DR: Immodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere‐specific localization during metaphase, and indicates the existence of a mammalian SU(VAR) complex.
Journal ArticleDOI
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
Götz Laible,Andrea Wolf,Rainer Dorn,Gunter Reuter,Corey Nislow,Angelika Lebersorger,Dan Popkin,Lorraine Pillus,Thomas Jenuwein +8 more
TL;DR: The isolation of human (EZH2) and mouse (Ezh1) homologues of the Drosophila Polycomb‐group (Pc‐G) gene Enhancer of zeste [E(z)], a crucial regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin, is described, indicating that silencing mechanism(s) may be broadly conserved in eukaryotes.
Journal ArticleDOI
Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice
Stefan Czvitkovich,Stephan Sauer,Antoine H.F.M. Peters,E M Deiner,Andrea Wolf,Götz Laible,Susanne Opravil,Hartmut Beug,Thomas Jenuwein +8 more
TL;DR: Evidence is provided for a role of the SUV39H1 HMTase during the mammalian development and indicate a possible function for higher-order chromatin in contributing to the balance between proliferation and differentiation potentials of progenitor cells.