A
Angelika Lebersorger
Researcher at Research Institute of Molecular Pathology
Publications - 4
Citations - 1082
Angelika Lebersorger is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Heterochromatin & Regulation of gene expression. The author has an hindex of 4, co-authored 4 publications receiving 1038 citations.
Papers
More filters
Journal ArticleDOI
Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31
Louise Aagaard,Götz Laible,Philipp Selenko,Manfred Schmid,Rainer Dorn,Gunnar Schotta,Steffi Kuhfittig,Andrea Wolf,Angelika Lebersorger,Prim B. Singh,Gunter Reuter,Thomas Jenuwein +11 more
TL;DR: Immodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere‐specific localization during metaphase, and indicates the existence of a mammalian SU(VAR) complex.
Journal ArticleDOI
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
Götz Laible,Andrea Wolf,Rainer Dorn,Gunter Reuter,Corey Nislow,Angelika Lebersorger,Dan Popkin,Lorraine Pillus,Thomas Jenuwein +8 more
TL;DR: The isolation of human (EZH2) and mouse (Ezh1) homologues of the Drosophila Polycomb‐group (Pc‐G) gene Enhancer of zeste [E(z)], a crucial regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin, is described, indicating that silencing mechanism(s) may be broadly conserved in eukaryotes.
Journal ArticleDOI
Isolation and Characterization of Suv39h2, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression
Dónal O'Carroll,Harry Scherthan,Antoine H.F.M. Peters,Susanne Opravil,Andrew R. Haynes,Götz Laible,Stephen Rea,Manfred Schmid,Angelika Lebersorger,Martin Jerratsch,Lydia Sattler,Marie Geneviève Mattei,Paul Denny,Stephen D.M. Brown,Dieter Schweizer,Thomas Jenuwein +15 more
TL;DR: Immunolocalization of Suv39h2 protein during spermatogenesis indicates enriched distribution at the heterochromatin from the leptotene to the round sperMatid stage, suggesting an additional function of the Suv 39h2 HMTase in organizing meiotic heterochromeatin that may even impart an epigenetic imprint to the male germ line.
Journal ArticleDOI
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse Chromosomes 11 and 6
Götz Laible,Andrew R. Haynes,Angelika Lebersorger,Dónal O'Carroll,Marie-Geneviève Mattei,Paul Denny,Steve D.M. Brown,Thomas Jenuwein +7 more
TL;DR: E(z) appears to be a pleiotropic Pc-G gene with functions in chromatin architecture, gene regulation, and growth control, and mammalian E(Z)related genes are likely to participate in developmental switches that may trigger differentiation or proliferation.