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Andreas Lüthi
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 80
Citations - 14700
Andreas Lüthi is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Amygdala & Fear conditioning. The author has an hindex of 49, co-authored 76 publications receiving 12409 citations. Previous affiliations of Andreas Lüthi include University of Basel.
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Neuronal circuits for fear and anxiety
TL;DR: This Review focuses on studies that have used circuit-based approaches to gain a more detailed, and also more comprehensive and integrated, view on how the brain governs fear and anxiety and how it orchestrates adaptive defensive behaviours.
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Switching on and off fear by distinct neuronal circuits
TL;DR: It is shown that bi-directional transitions between states of high and low fear are triggered by a rapid switch in the balance of activity between two distinct populations of basal amygdala neurons.
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Amygdala inhibitory circuits and the control of fear memory.
TL;DR: Current understanding and emerging concepts of how local inhibitory circuits in the amygdala control the acquisition, expression, and extinction of conditioned fear at different levels are reviewed.
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Encoding of conditioned fear in central amygdala inhibitory circuits
Stephane Ciocchi,Cyril Herry,Cyril Herry,François Grenier,Steffen B. E. Wolff,Johannes J. Letzkus,Ioannis Vlachos,Ingrid Ehrlich,Ingrid Ehrlich,Rolf Sprengel,Karl Deisseroth,Michael B. Stadler,Christian Müller,Andreas Lüthi +13 more
TL;DR: Functional circuit analysis revealed that inhibitory CEA microcircuits are highly organized and that cell-type-specific plasticity of phasic and tonic activity in the CEl to CEm pathway may gate fear expression and regulate fear generalization.
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A disinhibitory microcircuit for associative fear learning in the auditory cortex
Johannes J. Letzkus,Steffen B. E. Wolff,Steffen B. E. Wolff,Elisabeth M. M. Meyer,Elisabeth M. M. Meyer,Philip Tovote,Julien Courtin,Cyril Herry,Andreas Lüthi +8 more
TL;DR: It is demonstrated that stimulus convergence in the auditory cortex is necessary for associative fear learning to complex tones, define the circuit elements mediating this convergence and suggest that layer-1-mediated disinhibition is an important mechanism underlying learning and information processing in neocortical circuits.