J
Johannes J. Letzkus
Researcher at Max Planck Society
Publications - 32
Citations - 5225
Johannes J. Letzkus is an academic researcher from Max Planck Society. The author has contributed to research in topics: Associative learning & Optogenetics. The author has an hindex of 21, co-authored 29 publications receiving 4509 citations. Previous affiliations of Johannes J. Letzkus include Australian National University & Friedrich Miescher Institute for Biomedical Research.
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Journal ArticleDOI
Encoding of conditioned fear in central amygdala inhibitory circuits
Stephane Ciocchi,Cyril Herry,Cyril Herry,François Grenier,Steffen B. E. Wolff,Johannes J. Letzkus,Ioannis Vlachos,Ingrid Ehrlich,Ingrid Ehrlich,Rolf Sprengel,Karl Deisseroth,Michael B. Stadler,Christian Müller,Andreas Lüthi +13 more
TL;DR: Functional circuit analysis revealed that inhibitory CEA microcircuits are highly organized and that cell-type-specific plasticity of phasic and tonic activity in the CEl to CEm pathway may gate fear expression and regulate fear generalization.
Journal ArticleDOI
A disinhibitory microcircuit for associative fear learning in the auditory cortex
Johannes J. Letzkus,Steffen B. E. Wolff,Steffen B. E. Wolff,Elisabeth M. M. Meyer,Elisabeth M. M. Meyer,Philip Tovote,Julien Courtin,Cyril Herry,Andreas Lüthi +8 more
TL;DR: It is demonstrated that stimulus convergence in the auditory cortex is necessary for associative fear learning to complex tones, define the circuit elements mediating this convergence and suggest that layer-1-mediated disinhibition is an important mechanism underlying learning and information processing in neocortical circuits.
Journal ArticleDOI
Amygdala interneuron subtypes control fear learning through disinhibition
Steffen B. E. Wolff,Jan Gründemann,Philip Tovote,Sabine Krabbe,Gilad A. Jacobson,Christian Müller,Cyril Herry,Ingrid Ehrlich,Rainer W. Friedrich,Johannes J. Letzkus,Andreas Lüthi +10 more
TL;DR: It is demonstrated that associative learning is dynamically regulated by the stimulus-specific activation of distinct disinhibitory microcircuits through precise interactions between different subtypes of local interneurons.
Journal ArticleDOI
Long-range connectivity defines behavioral specificity of amygdala neurons
Verena Senn,Verena Senn,Steffen B. E. Wolff,Steffen B. E. Wolff,Cyril Herry,François Grenier,Ingrid Ehrlich,Jan Gründemann,Jonathan P. Fadok,Christian Müller,Johannes J. Letzkus,Andreas Lüthi +11 more
TL;DR: These findings demonstrate that, although intermingled locally, long-range connectivity defines distinct subpopulations of amygdala projection neurons and indicate that the formation of long-term extinction memories depends on the balance of activity between two defined amygdala-prefrontal pathways.
Journal ArticleDOI
Neuronal circuits of fear extinction.
Cyril Herry,Francesco Ferraguti,Nicolas Singewald,Johannes J. Letzkus,Ingrid Ehrlich,Andreas Lüthi +5 more
TL;DR: Emerging concepts of the neuronal circuitry of fear extinction are reviewed, and novel findings suggesting that the fragile phenomenon of extinction can be converted into a permanent erasure of fear memories are highlighted.