A
Andrew Freiman
Researcher at Wayne State University
Publications - 3
Citations - 441
Andrew Freiman is an academic researcher from Wayne State University. The author has contributed to research in topics: Adaptation & Expression quantitative trait loci. The author has an hindex of 2, co-authored 3 publications receiving 318 citations.
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Journal ArticleDOI
Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens
Yohann Nédélec,Yohann Nédélec,Joaquín Sanz,Joaquín Sanz,Golshid Baharian,Golshid Baharian,Zachary A. Szpiech,Alain Pacis,Alain Pacis,Anne Dumaine,Jean-Christophe Grenier,Andrew Freiman,Aaron J. Sams,Steven Hebert,Ariane Pagé Sabourin,Francesca Luca,Ran Blekhman,Ryan D. Hernandez,Roger Pique-Regi,Jenny Tung,Vania Yotova,Luis B. Barreiro,Luis B. Barreiro +22 more
TL;DR: It is shown that genetic effects on the immune response are strongly enriched for recent, population-specific signatures of adaptation, including for traits that are key to controlling infection.
Journal ArticleDOI
High-throughput characterization of genetic effects on DNA-protein binding and gene transcription.
Cynthia A Kalita,Christopher D. Brown,Andrew Freiman,Jenna Isherwood,Xiaoquan Wen,Roger Pique-Regi,Francesca Luca +6 more
TL;DR: A streamlined protocol for a high-throughput reporter assay that identifies allele-specific expression (ASE) while accounting for PCR duplicates through unique molecular identifiers is developed, characterized that the Crohn's disease risk variant for rs3810936 increases NFKB1 binding and results in altered gene expression.
Posted ContentDOI
High throughput characterization of genetic effects on DNA:protein binding and gene transcription
Cynthia A Kalita,Christopher D. Brown,Andrew Freiman,Jenna Isherwood,Xiaoquan Wen,Roger Pique-Regi,Francesca Luca +6 more
TL;DR: A streamlined protocol for a high-throughput reporter assay that identifies allele-specific expression (ASE) while accounting for PCR duplicates through unique molecular identifiers is developed, characterized that the Crohn’s disease risk variant for rs3810936 increases NFKB binding and results in altered gene expression.