J
Jean-Christophe Grenier
Researcher at Université de Montréal
Publications - 41
Citations - 3044
Jean-Christophe Grenier is an academic researcher from Université de Montréal. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 18, co-authored 31 publications receiving 2181 citations. Previous affiliations of Jean-Christophe Grenier include Centre Hospitalier Universitaire Sainte-Justine & Ontario Institute for Cancer Research.
Papers
More filters
Journal ArticleDOI
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
Eva Kaufmann,Joaquín Sanz,Jonathan L. Dunn,Nargis Khan,Laura Mendonca,Alain Pacis,Fanny Tzelepis,Erwan Pernet,Anne Dumaine,Jean-Christophe Grenier,Florence Mailhot-Léonard,Eisha Ahmed,Jad I. Belle,Rickvinder Besla,Bruce Mazer,Irah L. King,Anastasia Nijnik,Clinton S. Robbins,Luis B. Barreiro,Maziar Divangahi +19 more
TL;DR: It is shown that access of Bacillus Calmette-Guérin to the bone marrow changes the transcriptional landscape of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs), leading to local cell expansion and enhanced myelopoiesis at the expense of lymphopoiedis.
Journal ArticleDOI
Social networks predict gut microbiome composition in wild baboons.
Jenny Tung,Luis B. Barreiro,Michael B. Burns,Jean-Christophe Grenier,Josh Lynch,Laura E. Grieneisen,Jeanne Altmann,Susan C. Alberts,Ran Blekhman,Elizabeth A. Archie +9 more
TL;DR: Using shotgun metagenomic data from wild baboons, it is found that social group membership and social network relationships predicted both the taxonomic structure of the gut microbiome and the structure of genes encoded by gut microbial species.
Journal ArticleDOI
Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens
Yohann Nédélec,Yohann Nédélec,Joaquín Sanz,Joaquín Sanz,Golshid Baharian,Golshid Baharian,Zachary A. Szpiech,Alain Pacis,Alain Pacis,Anne Dumaine,Jean-Christophe Grenier,Andrew Freiman,Aaron J. Sams,Steven Hebert,Ariane Pagé Sabourin,Francesca Luca,Ran Blekhman,Ryan D. Hernandez,Roger Pique-Regi,Jenny Tung,Vania Yotova,Luis B. Barreiro,Luis B. Barreiro +22 more
TL;DR: It is shown that genetic effects on the immune response are strongly enriched for recent, population-specific signatures of adaptation, including for traits that are key to controlling infection.
Journal ArticleDOI
Social status alters immune regulation and response to infection in macaques
Noah Snyder-Mackler,Joaquín Sanz,Joaquín Sanz,Jordan N. Kohn,Jessica F. Brinkworth,Jessica F. Brinkworth,Shauna Morrow,Amanda O. Shaver,Jean-Christophe Grenier,Roger Pique-Regi,Zachary P. Johnson,Zachary P. Johnson,Mark E. Wilson,Mark E. Wilson,Luis B. Barreiro,Luis B. Barreiro,Jenny Tung +16 more
TL;DR: Genomics is combined with social status manipulation in female rhesus macaques to investigate how status alters immune function, and causal but largely plastic social status effects on immune cell proportions, cell type–specific gene expression levels, and the gene expression response to immune challenge are demonstrated.
Journal ArticleDOI
Bacterial infection remodels the DNA methylation landscape of human dendritic cells
Alain Pacis,Alain Pacis,Ludovic Tailleux,Alexander M. Morin,John J. Lambourne,Julia L. MacIsaac,Vania Yotova,Anne Dumaine,Anne Danckaert,Francesca Luca,Jean-Christophe Grenier,Kasper D. Hansen,Brigitte Gicquel,Miao Yu,Athma A. Pai,Chuan He,Jenny Tung,Tomi Pastinen,Michael S. Kobor,Roger Pique-Regi,Yoav Gilad,Luis B. Barreiro,Luis B. Barreiro +22 more
TL;DR: It is demonstrated that the infection of human dendritic cells with a live pathogenic bacteria is associated with rapid and active demethylation at thousands of loci, independent of cell division, and play a previously unappreciated role in regulating the transcriptional response to infection.