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Andrew G. W. Leslie
Researcher at Laboratory of Molecular Biology
Publications - 86
Citations - 33243
Andrew G. W. Leslie is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: ATPase & ATP synthase. The author has an hindex of 51, co-authored 85 publications receiving 30306 citations.
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Journal ArticleDOI
Overview of the CCP4 suite and current developments.
Martyn Winn,Charles Ballard,Kevin Cowtan,Eleanor J. Dodson,Paul Emsley,Phil Evans,Ronan M. Keegan,Eugene Krissinel,Andrew G. W. Leslie,Airlie J. McCoy,Stuart McNicholas,Garib N. Murshudov,Navraj S. Pannu,E. Potterton,Harold R. Powell,Randy J. Read,Alexei A. Vagin,Keith S. Wilson +17 more
TL;DR: An overview of the CCP4 software suite for macromolecular crystallography is given.
Journal ArticleDOI
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.
TL;DR: The crystal structure of bovine mitochondrial F1-ATPase determined at 2.8 Å resolution supports a catalytic mechanism in intact ATP synthase in which the three catalytic subunits are in different states of the catalytic cycle at any instant.
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iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM
TL;DR: A new graphical user interface to the MOSFLM program has been developed to simplify the processing of macromolecular diffraction data and provides visual feedback on the progress of each stage.
Journal ArticleDOI
Structure of a beta1-adrenergic G-protein-coupled receptor.
Tony Warne,Maria Josefa Serrano-Vega,Jillian G. Baker,Rouslan Moukhametzianov,Patricia C. Edwards,Richard Henderson,Andrew G. W. Leslie,Christopher G. Tate,Gebhard F. X. Schertler +8 more
TL;DR: G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets and here the 2.7 Å resolution crystal structure of a β1-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol is reported.
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The integration of macromolecular diffraction data
TL;DR: These equations highlight the importance of the contribution of the X-ray background to the standard error and give an estimate of the improvement which can be achieved by profile fitting.