Andrew J. Malcolm

TL;DR: A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.

TL;DR: Peritransplant intensive insulin and heparin enhances islet transplantation outcomes likely related in part to mitigation of the effects of the instant blood-mediated inflammatory reaction, combined with islet rest and avoidance of inflammation.

TL;DR: In this paper, the 1-hour signal represents dead beta cells carried over into the recipient after islet isolation and culture, combined with acute cell death post infusion, and was also detected 24 hours posttransplant (8/37 subjects, 21.6%).

TL;DR: It is shown that chicken IgY antibodies to α‐Gal antigen epitopes and to other porcine aortic endothelial cell (PAEC) antigens block human xenoreactive natural antibody binding to both Porcine and rat cardiac tissues and porcines kidney tissues, suggesting that avian IgYs could be of potential use in inhibiting pig‐to‐human xenograft rejection.

TL;DR: Using current protocols, SII in the absence of exenatide results in impressive insulin-independence rates and the durability of insulin independence seems to be promising, however, a beneficial effect of exENatide should not be discounted until tested in randomized controlled studies.