A
Andrew K. Brown
Researcher at Hull York Medical School
Publications - 34
Citations - 4695
Andrew K. Brown is an academic researcher from Hull York Medical School. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 23, co-authored 34 publications receiving 4480 citations. Previous affiliations of Andrew K. Brown include University of Leeds & Chapel Allerton Hospital.
Papers
More filters
Journal Article
Musculoskeletal ultrasound including definitions for ultrasonographic pathology
Richard J. Wakefield,Peter V. Balint,Marcin Szkudlarek,Emilio Filippucci,Marina Backhaus,Maria Antonietta D'Agostino,Esperanza Naredo Sanchez,Annamaria Iagnocco,Wolfgang A. Schmidt,George A W Bruyn,David Kane,Philip O'Connor,Bernhard Manger,Fred Joshua,Juhani M. Koski,Walter Grassi,Marissa Lassere,Nanno Swen,Franz Kainberger,Andrea Klauser,Mikkel Østergaard,Andrew K. Brown,Klaus P Machold,Philip G. Conaghan +23 more
TL;DR: The first report from the OMERACT ultrasound special interest group is presented, which has compared US against the criteria of the O MERACT filter, and for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.
Journal ArticleDOI
An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
Andrew K. Brown,Philip G. Conaghan,Zunaid Karim,Mark A. Quinn,Kei Ikeda,Charles Peterfy,Elizabeth M A Hensor,Richard J. Wakefield,Philip O'Connor,Paul Emery +9 more
TL;DR: Subclinical joint inflammation detected by imaging techniques explains the structural deterioration in RA patients in clinical remission who are receiving conventional therapy and reinforces the utility of imaging for the accurate evaluation of disease status and the prediction of structural outcome.
Journal ArticleDOI
Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression.
Andrew K. Brown,Mark A. Quinn,Zunaid Karim,Philip G. Conaghan,Charles Peterfy,Elizabeth M A Hensor,Richard J. Wakefield,Philip O'Connor,Paul Emery +8 more
TL;DR: Most RA patients who satisfied the remission criteria with normal findings on clinical and laboratory studies had imaging-detected synovitis, which may explain the observed discrepancy between disease activity and outcome in RA.
Journal ArticleDOI
Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
Mark A. Quinn,Philip G. Conaghan,Philip O'Connor,Zunaid Karim,Adam Greenstein,Andrew K. Brown,Clare Brown,Alexander Fraser,Stephen Jarret,Paul Emery +9 more
TL;DR: Remission induction with infliximab plus MTX provided a significant reduction in MRI evidence of synovitis and erosions at 1 year, and functional and quality of life benefits were sustained, despite withdrawal of inflIXimab therapy, which may have significant implications for the optimal use of expensive biologic therapies.
Journal ArticleDOI
Validation and reproducibility of ultrasonography in the detection of synovitis in the knee-A comparison with arthroscopy and clinical examination
Zunaid Karim,Richard J. Wakefield,Mark A. Quinn,Philip G. Conaghan,Andrew K. Brown,Douglas J. Veale,Philip O'Connor,Richard Reece,Paul Emery +8 more
TL;DR: Ulasonography is a valid and reproducible technique for detecting synovitis in the knee, and is more accurate than clinical examination, and may be valuable as a tool in studies investigating pain, diagnosis, and treatment response in knee arthritis.