Open AccessJournal Article
Musculoskeletal ultrasound including definitions for ultrasonographic pathology
Richard J. Wakefield,Peter V. Balint,Marcin Szkudlarek,Emilio Filippucci,Marina Backhaus,Maria Antonietta D'Agostino,Esperanza Naredo Sanchez,Annamaria Iagnocco,Wolfgang A. Schmidt,George A W Bruyn,David Kane,Philip O'Connor,Bernhard Manger,Fred Joshua,Juhani M. Koski,Walter Grassi,Marissa Lassere,Nanno Swen,Franz Kainberger,Andrea Klauser,Mikkel Østergaard,Andrew K. Brown,Klaus P Machold,Philip G. Conaghan +23 more
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TLDR
The first report from the OMERACT ultrasound special interest group is presented, which has compared US against the criteria of the O MERACT filter, and for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.Abstract:
Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy. It has a number of distinct advantages over magnetic resonance imaging, including good patient tolerability and ability to scan multiple joints in a short period of time. However, there are scarce data regarding its validity, reproducibility, and responsiveness to change, making interpretation and comparison of studies difficult. In particular, there are limited data describing standardized scanning methodology and standardized definitions of US pathologies. This article presents the first report from the OMERACT ultrasound special interest group, which has compared US against the criteria of the OMERACT filter. Also proposed for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.read more
Citations
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An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
Andrew K. Brown,Philip G. Conaghan,Zunaid Karim,Mark A. Quinn,Kei Ikeda,Charles Peterfy,Elizabeth M A Hensor,Richard J. Wakefield,Philip O'Connor,Paul Emery +9 more
TL;DR: Subclinical joint inflammation detected by imaging techniques explains the structural deterioration in RA patients in clinical remission who are receiving conventional therapy and reinforces the utility of imaging for the accurate evaluation of disease status and the prediction of structural outcome.
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Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression.
Andrew K. Brown,Mark A. Quinn,Zunaid Karim,Philip G. Conaghan,Charles Peterfy,Elizabeth M A Hensor,Richard J. Wakefield,Philip O'Connor,Paul Emery +8 more
TL;DR: Most RA patients who satisfied the remission criteria with normal findings on clinical and laboratory studies had imaging-detected synovitis, which may explain the observed discrepancy between disease activity and outcome in RA.
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Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project.
Marina Backhaus,Sarah Ohrndorf,Herbert Kellner,J. Strunk,T. M. Backhaus,Wolfgang Hartung,H. Sattler,Katinka Albrecht,J. Kaufmann,Karsten Becker,H. Sörensen,L. Meier,G.-R. Burmester,Wolfgang A. Schmidt +13 more
TL;DR: The German US7 score is a viable tool for examining patients with arthritis in daily rheumatologic practice because it significantly reflects therapeutic response.
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Osteoarthritis: Pathology, Diagnosis, and Treatment Options.
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Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Fumitaka Mizoguchi,Kamil Slowikowski,Kevin Wei,Jennifer L. Marshall,Deepak A. Rao,Sook Kyung Chang,Hung N. Nguyen,Erika H. Noss,Erika H. Noss,Jason D. Turner,Brandon E. Earp,Philip E. Blazar,John Wright,Barry P. Simmons,Laura T. Donlin,George D. Kalliolias,Susan M. Goodman,Susan M. Goodman,Vivian P. Bykerk,Vivian P. Bykerk,Lionel B. Ivashkiv,Lionel B. Ivashkiv,James A. Lederer,Nir Hacohen,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,Soumya Raychaudhuri,Michael B. Brenner +29 more
TL;DR: Functional and transcriptional differences between fibroblast subsets from human synovial tissues are shown using bulk transcriptomics of targeted subpopulations and single-cell transcriptomics for rheumatoid arthritis.
References
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Journal ArticleDOI
Guidelines for musculoskeletal ultrasound in rheumatology
Marina Backhaus,Gerd-Rüdiger Burmester,Gerber T,Walter Grassi,K P Machold,Wijnand A. A. Swen,Richard J. Wakefield,B Manger +7 more
TL;DR: US is most commonly used in the assessment of soft tissue disease or detection of fluid collection and can also be used to visualise other structures, such as cartilage and bone surfaces, and its ability to be repeated as often as necessary makes it particularly useful for the monitoring of treatment.
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Musculoskeletal ultrasound—a state of the art review in rheumatology. Part 2: Clinical indications for musculoskeletal ultrasound in rheumatology
TL;DR: There is exciting evidence that MSUS may potentially be used by rheumatologists to non-invasively diagnose and monitor not just joint and muscle disease but also nerve compression syndromes, scleroderma, vasculitis and Sjögren's syndrome.
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The current status of ultrasonography in rheumatology.
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Imaging in rheumatoid arthritis--why MRI and ultrasonography can no longer be ignored.
TL;DR: Current knowledge on conventional radiography, computed tomography, MRI and US for assessment of peripheral joints in RA is reviewed and the rationale is provided for MRI being the new gold standard for Assessment of RA joints and US becoming a routine bedside tool for improved joint assessments and injections by rheumatologists.
Journal Article
Measurements of rheumatoid arthritis disease activity and damage using magnetic resonance imaging. Truth and discrimination: does MRI make the grade?
Marissa Lassere,Paul Bird +1 more
TL;DR: It is regrettable if MRI measures are developed ad hoc, with little regard to considerations of scaling, reliability, validity, and responsiveness to change, because this will severely limit their ability to confidently assess treatment efficacy and prognostic indicators.
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