Bernhard Manger

TL;DR: The first report from the OMERACT ultrasound special interest group is presented, which has compared US against the criteria of the O MERACT filter, and for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.

TL;DR: It is reported that neutrophils recruited to sites of inflammation undergo oxidative burst and form neutrophil extracellular traps (NETs), and aggregated NETs promote the resolution of neutrophilic inflammation by degrading cytokines and chemokines and disrupting neutrophIL recruitment and activation.

TL;DR: Therapy with infliximab at a dose of 5 mg/kg significantly improved the signs and symptoms of arthritis, psoriasis, dactylitis, and enthesitis in patients with active PsA that had been resistant to DMARD therapy.

TL;DR: It is suggested that in a sub-group of SLE patients, apoptotic cells are not properly cleared by tingible body macrophages of the GCs, and nuclear autoantigens bind to FDCs and may thus provide survival signals for autoreactive B cells.

TL;DR: The concept that bone damage is an exclusive consequence of synovitis in patients with RA is revised, as structural bone damage starts before the clinical onset of arthritis in subjects with ACPA.