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Andrew M. Leidal
Researcher at University of California, San Francisco
Publications - 34
Citations - 2287
Andrew M. Leidal is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Autophagy & Secretion. The author has an hindex of 14, co-authored 31 publications receiving 1676 citations. Previous affiliations of Andrew M. Leidal include Dalhousie University & University of Toronto.
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Journal ArticleDOI
Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis
Paola Marcato,Cheryl A. Dean,Da Pan,Rakhna Araslanova,Megan E. Gillis,Madalsa Joshi,Lucy Helyer,Lu-Zhe Pan,Andrew M. Leidal,Shashi Gujar,Carman A. Giacomantonio,Patrick W. K. Lee +11 more
TL;DR: The results identified ALDH1A3 as a novel CSC marker with potential clinical prognostic applicability, and demonstrate a clear correlation between CSC prevalence and the development of metastatic breast cancer, as well as shRNA knockdown experiments of the various ALDH isoforms.
Journal ArticleDOI
Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression
TL;DR: It is demonstrated that Smaug interacts with the Cup protein and that Cup is an eIF4E‐binding protein that blocks the binding of eIF3G to eIF 4E, which represses translation via a Cup‐dependent block in eif4G recruitment.
Journal ArticleDOI
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
Andrew M. Leidal,Hector H. Huang,Timothy Marsh,Tina Solvik,Dachuan Zhang,Jordan Ye,FuiBoon Kai,Juliet Goldsmith,Jennifer Y. Liu,Yu-Hsin Huang,Teresa Monkkonen,Ariadne Vlahakis,Eric J. Huang,Hani Goodarzi,Li Yu,Arun P. Wiita,Jayanta Debnath +16 more
TL;DR: It is shown that the LC3-conjugation pathway, which is part of the autophagy machinery, controls extracellular vesicle cargo loading and secretion of RNA-binding proteins.
Journal ArticleDOI
Autophagy and the cell biology of age-related disease
TL;DR: How the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan is examined.
Journal ArticleDOI
Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion
TL;DR: It is demonstrated that an intact autophagy pathway is required for the elaboration of multiple secreted factors favoring invasion, including IL-6, which reduces the secretion of the promigratory cytokine interleukin-6 (IL-6), which is necessary to restore invasion of autophile-deficient cells.