H
Hani Goodarzi
Researcher at University of California, San Francisco
Publications - 120
Citations - 7989
Hani Goodarzi is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 33, co-authored 83 publications receiving 5504 citations. Previous affiliations of Hani Goodarzi include Rockefeller University & Columbia University.
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N6-methyladenosine marks primary microRNAs for processing
TL;DR: These findings reveal that the m6A mark acts as a key post-transcriptional modification that promotes the initiation of miRNA biogenesis and that METTL3 is sufficient to enhance miRNA maturation in a global and non-cell-type-specific manner.
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HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
TL;DR: HNRNPA2B1 is proposed to be a nuclear reader of the m(6)A mark and to mediate, in part, this mark's effects on primary microRNA processing and alternative splicing.
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Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement
TL;DR: These findings reveal a tumor-suppressive role for specific tRNA-derived fragments and describe a molecular mechanism for their action, which may generalize to other tRNA, ribosomal-RNA, and sno-RNA fragments.
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Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
Manav Korpal,Brian Ell,Francesca M. Buffa,Toni Ibrahim,Mario Andres Blanco,Toni Celià-Terrassa,Laura Mercatali,Zia Khan,Hani Goodarzi,Yuling Hua,Yong Wei,Guohong Hu,Benjamin A. Garcia,Jiannis Ragoussis,Dino Amadori,Adrian L. Harris,Yibin Kang +16 more
TL;DR: A pleiotropic role of miR-200s is suggested in promoting metastatic colonization by influencing E-cadherin–dependent epithelial traits and Sec23a-mediated tumor cell secretome.
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A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu,Emiko T.A. Morimoto,Hani Goodarzi,Jennifer T. Liao,Sean O'Keeffe,Hemali Phatnani,Michael Muratet,Michael C. Carroll,Shawn Levy,Saeed Tavazoie,Richard M. Myers,Tom Maniatis +11 more
TL;DR: It is found that SOD1(G93A) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including Alzheimer's disease genes, are concurrently upregulated.