A
Andrew V. Nguyen
Researcher at City University of New York
Publications - 29
Citations - 3050
Andrew V. Nguyen is an academic researcher from City University of New York. The author has contributed to research in topics: Tumor progression & Breast cancer. The author has an hindex of 14, co-authored 29 publications receiving 2820 citations. Previous affiliations of Andrew V. Nguyen include Queensborough Community College & University of Connecticut.
Papers
More filters
Journal ArticleDOI
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy.
TL;DR: It is demonstrated that the growth of mammary tumors and the development to malignancy are separate processes and that CSF-1 selectively promotes the latter process, and that agents directed at CSf-1/CSF- 1R activity could have important therapeutic effects.
Journal ArticleDOI
The macrophage growth factor CSF-1 in mammary gland development and tumor progression.
TL;DR: Observations suggest that the tumors subvert normal developmental processes to allow invasion into the surrounding stroma, a process that gives the tumor access to the vasculature and consequently the promotion of metastasis.
Journal ArticleDOI
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.
Lin Deng,Jin Feng Zhou,Rani S. Sellers,Jiu Feng Li,Andrew V. Nguyen,Yubao Wang,Amos Orlofsky,Qiang Liu,David A. Hume,Jeffrey W. Pollard,Leonard H. Augenlicht,Elaine Y. Lin +11 more
TL;DR: A novel mouse model of IBD-colorectal cancer progression is established in which disrupted immune regulation, mTOR-Stat3 signaling, and epithelial hyperproliferation are integrated and simultaneously linked to the development of malignancy.
Journal ArticleDOI
Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.
TL;DR: Evidence is provided that immediately following weaning TGFbeta3 mRNA and protein is rapidly induced in the mammary epithelium and that this precedes the onset of apoptosis, which is direct evidence that TGF beta3 is a local mammary factor induced by milk stasis that causes apoptosis in the Mammary gland epithelia during involution.
Journal ArticleDOI
Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth.
TL;DR: Data show that macrophages acting locally are required for branching morphogenesis of the mammary gland, and inhibition of CSF-1 expression by tetracycline treatment for varying periods suggested that CSf-1-regulatedmacrophages are required throughout early mammary glands development.