L
Leonard H. Augenlicht
Researcher at Albert Einstein College of Medicine
Publications - 169
Citations - 12713
Leonard H. Augenlicht is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Cellular differentiation & Apoptosis. The author has an hindex of 59, co-authored 162 publications receiving 11861 citations. Previous affiliations of Leonard H. Augenlicht include Montefiore Medical Center & Yeshiva University.
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Journal ArticleDOI
Colorectal cancer in mice genetically deficient in the mucin Muc2.
Anna Velcich,Wancai Yang,Joerg Heyer,Alessandra Fragale,Courtney Nicholas,Stephanie Viani,Raju Kucherlapati,Martin Lipkin,Kan Yang,Leonard H. Augenlicht +9 more
TL;DR: Muc2 is involved in the suppression of colorectal cancer and frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors.
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Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer
Andrew J. Wilson,Do Sun Byun,Natalia Popova,Lucas B. Murray,Kaitlin L’italien,Yoshihiro Sowa,Diego Arango,Anna Velcich,Leonard H. Augenlicht,John M. Mariadason +9 more
TL;DR: HDAC3 is identified as a gene deregulated in human colon cancer and as a novel regulator of colon cell maturation and p21 expression and it is suggested that the growth-inhibitory and apoptotic effects induced by HDAC inhibitors are probably mediated through the inhibition of multiple HDACs.
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Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Meimei Shan,Maurizio Gentile,John R. Yeiser,A. Cooper Walland,Victor Ugarte Bornstein,Kang Chen,Kang Chen,Bing He,Linda Cassis,Anna Bigas,Montserrat Cols,Laura Comerma,Bihui Huang,J. Magarian Blander,Huabao Xiong,Lloyd Mayer,Cecilia Berin,Leonard H. Augenlicht,Anna Velcich,Andrea Cerutti +19 more
TL;DR: It is shown that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs) and constrains the immunogenicity of gut antigens by delivering tolerogenic signals.
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PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab
Minaxi Jhawer,Sanjay Goel,Andrew J. Wilson,Cristina Montagna,Yi He Ling,Do Sun Byun,Shannon Nasser,Diego Arango,Joongho Shin,Lidija Klampfer,Leonard H. Augenlicht,Roman Perez Soler,John M. Mariadason +12 more
TL;DR: A priori screening of colon tumors for PTEN expression status and PIK3CA and Ras/BRAF mutation status could help stratify patients likely to benefit from this therapy.
Journal Article
Genetic Reprogramming in Pathways of Colonic Cell Maturation Induced by Short Chain Fatty Acids: Comparison with Trichostatin A, Sulindac, and Curcumin and Implications for Chemoprevention of Colon Cancer
TL;DR: High-throughput microarray analysis of gene expression profiles can be used to characterize and distinguish the mechanisms of response of colonic epithelial cells to physiological and pharmacological inducers of cell maturation, which has important implications for characterization of chemopreventive agents and recognition of potential toxicity and synergies.