A
Andy Barthorpe
Researcher at Wellcome Trust Sanger Institute
Publications - 2
Citations - 1096
Andy Barthorpe is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Anaplastic lymphoma kinase & Cancer. The author has an hindex of 2, co-authored 2 publications receiving 1037 citations.
Papers
More filters
Journal ArticleDOI
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Philip J. Stephens,Christopher I. Hunter,Graham R. Bignell,Sarah Edkins,Helen Davies,Jon W. Teague,Claire Stevens,Sarah O’Meara,Raffaella Smith,Adrian Parker,Andy Barthorpe,Matthew J. Blow,Lisa Brackenbury,Adam Butler,Oliver Clarke,Jennifer Cole,Ed Dicks,Angus Dike,Anja Drozd,Ken Edwards,Simon A. Forbes,Rebecca Foster,Kristian Gray,Christopher Greenman,Kelly Halliday,Katy Hills,Vivienne Kosmidou,Richard Lugg,Andy Menzies,Janet Perry,Robert Petty,Keiran Raine,Lewis Ratford,Rebecca Shepherd,Alexandra Small,Yvonne Stephens,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Margaret A. Knowles,Suet Yi Leung,David N. Louis,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Georgia Chenevix-Trench,Barbara L. Weber,Siu Tsan Yuen,Grace Harris,Peter Goldstraw,Andrew G. Nicholson,P. Andrew Futreal,Richard Wooster,Michael R. Stratton,Michael R. Stratton +60 more
TL;DR: The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies as mentioned in this paper.
Journal ArticleDOI
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Philip J. Stephens,Sarah Edkins,Helen Davies,Christopher Greenman,Charles Cox,Christopher I. Hunter,Graham R. Bignell,Jon W. Teague,Raffaella Smith,Claire Stevens,Sarah O’Meara,Adrian Parker,Patrick S. Tarpey,Tim Avis,Andy Barthorpe,Lisa Brackenbury,Gemma Buck,Adam Butler,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David T. Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Siu Tsan Yuen,Andrew G. Nicholson,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal,Richard Wooster +65 more
TL;DR: In many tumors, the coding sequence of 518 protein kinases was examined, and a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.