R
Rachel Harrison
Researcher at Wellcome Trust Sanger Institute
Publications - 11
Citations - 4767
Rachel Harrison is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Mutation & Gene. The author has an hindex of 8, co-authored 9 publications receiving 4495 citations. Previous affiliations of Rachel Harrison include Wellcome Trust.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer
Helen Davies,Christopher I. Hunter,Raffaella Smith,Philip J. Stephens,Christopher Greenman,Graham R. Bignell,Jon W. Teague,Adam Butler,Sarah Edkins,Claire Stevens,Adrian Parker,Sarah O’Meara,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Tean Teh,Siu Tsan Yuen,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Peter Goldstraw,Andrew G. Nicholson,Richard Wooster,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +64 more
TL;DR: The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent.
Journal ArticleDOI
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Ogechi Ikediobi,Helen Davies,Graham R. Bignell,Sarah Edkins,Claire Stevens,Sarah O’Meara,Thomas Santarius,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Adam Butler,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathan Hinton,Christopher I. Hunter,Andy Jenkinson,David T. Jones,Vivienne Kosmidou,Richard Lugg,Andrew Menzies,Tatiana Mironenko,Adrian Parker,Janet Perry,Keiran Raine,David S. Richardson,Rebecca Shepherd,Alex Small,Raffaella Smith,Helen Solomon,Philip J. Stephens,Jon W. Teague,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,William C. Reinhold,John N. Weinstein,Michael R. Stratton,P. Andrew Futreal,Richard Wooster +48 more
TL;DR: Identification of those cancer genes mutated in the NCI-60, in combination with pharmacologic and molecular profiles of the cells, will allow for more informed interpretation of anticancer agent screening and will enhance the use of the NCi-60 cell lines for molecularly targeted screens.
Journal ArticleDOI
A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy
Christopher I. Hunter,Raffaella Smith,Daniel P. Cahill,Philip J. Stephens,Claire Stevens,Jon W. Teague,Christopher Greenman,Sarah Edkins,Graham R. Bignell,Helen Davies,Sarah O’Meara,Adrian Parker,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Adam Butler,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,Andy Jenkinson,David T. Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,David S. Richardson,Rebecca Shepherd,Alexandra Small,Helen Solomon,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Douglas F. Easton,Gregory J. Riggins,Jennifer E. Roy,Kymberly K. Levine,Wolf Mueller,Tracy T. Batchelor,David N. Louis,Michael R. Stratton,P. Andrew Futreal,Richard Wooster +54 more
TL;DR: The evidence suggests that when MSH6 is inactivated in gliomas, alkylating agents convert from induction of tumor cell death to promotion of neoplastic progression, and the potential of large scale sequencing for revealing and elucidating mutagenic processes operative in individual human cancers is highlighted.
Journal ArticleDOI
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Philip J. Stephens,Sarah Edkins,Helen Davies,Christopher Greenman,Charles Cox,Christopher I. Hunter,Graham R. Bignell,Jon W. Teague,Raffaella Smith,Claire Stevens,Sarah O’Meara,Adrian Parker,Patrick S. Tarpey,Tim Avis,Andy Barthorpe,Lisa Brackenbury,Gemma Buck,Adam Butler,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David T. Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Siu Tsan Yuen,Andrew G. Nicholson,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal,Richard Wooster +65 more
TL;DR: In many tumors, the coding sequence of 518 protein kinases was examined, and a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.