M
Margaret A. Knowles
Researcher at University of Leeds
Publications - 247
Citations - 18185
Margaret A. Knowles is an academic researcher from University of Leeds. The author has contributed to research in topics: Bladder cancer & Loss of heterozygosity. The author has an hindex of 75, co-authored 242 publications receiving 16801 citations. Previous affiliations of Margaret A. Knowles include St James's University Hospital & University of Southern California.
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Journal ArticleDOI
Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
TL;DR: Improved understanding of molecular features, disease pathogenesis and heterogeneity provides new opportunities for prognostic application, disease monitoring and personalized therapy in urothelial cancer.
Journal ArticleDOI
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Philip J. Stephens,Christopher I. Hunter,Graham R. Bignell,Sarah Edkins,Helen Davies,Jon W. Teague,Claire Stevens,Sarah O’Meara,Raffaella Smith,Adrian Parker,Andy Barthorpe,Matthew J. Blow,Lisa Brackenbury,Adam Butler,Oliver Clarke,Jennifer Cole,Ed Dicks,Angus Dike,Anja Drozd,Ken Edwards,Simon A. Forbes,Rebecca Foster,Kristian Gray,Christopher Greenman,Kelly Halliday,Katy Hills,Vivienne Kosmidou,Richard Lugg,Andy Menzies,Janet Perry,Robert Petty,Keiran Raine,Lewis Ratford,Rebecca Shepherd,Alexandra Small,Yvonne Stephens,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Margaret A. Knowles,Suet Yi Leung,David N. Louis,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Georgia Chenevix-Trench,Barbara L. Weber,Siu Tsan Yuen,Grace Harris,Peter Goldstraw,Andrew G. Nicholson,P. Andrew Futreal,Richard Wooster,Michael R. Stratton,Michael R. Stratton +60 more
TL;DR: The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies as mentioned in this paper.
Journal ArticleDOI
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nathaniel Rothman,Montserrat Garcia-Closas,Nilanjan Chatterjee,Núria Malats,Xifeng Wu,Jonine D. Figueroa,Francisco X. Real,David Van Den Berg,Giuseppe Matullo,Dalsu Baris,Michael J. Thun,Lambertus A. Kiemeney,Paolo Vineis,Immaculata De Vivo,Demetrius Albanes,Mark P. Purdue,Thorunn Rafnar,Michelle A.T. Hildebrandt,Anne E. Kiltie,Olivier Cussenot,Klaus Golka,Rajesh Kumar,Jack A. Taylor,Jose I. Mayordomo,Kevin B. Jacobs,Manolis Kogevinas,Amy Hutchinson,Zhaoming Wang,Yi-Ping Fu,Ludmila Prokunina-Olsson,Laurie Burdett,Meredith Yeager,William Wheeler,Adonina Tardón,Consol Serra,Alfredo Carrato,Reina García-Closas,Josep Lloreta,Alison Johnson,Molly Schwenn,Margaret R. Karagas,Alan R. Schned,Gerald L. Andriole,Robert L. Grubb,Amanda Black,Eric J. Jacobs,W. Ryan Diver,Susan M. Gapstur,Stephanie J. Weinstein,Jarmo Virtamo,Victoria K. Cortessis,Manuela Gago-Dominguez,Malcolm C. Pike,Malcolm C. Pike,Mariana C. Stern,Jian-Min Yuan,David J. Hunter,Monica McGrath,Colin P.N. Dinney,Bogdan Czerniak,Meng Chen,Hushan Yang,Sita H. Vermeulen,Katja K.H. Aben,J. Alfred Witjes,Remco R. R. Makkinje,Patrick Sulem,Søren Besenbacher,Kari Stefansson,Kari Stefansson,Elio Riboli,Paul Brennan,Salvatore Panico,Carmen Navarro,Naomi E. Allen,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Neil E. Caporaso,Maria Teresa Landi,Federico Canzian,Börje Ljungberg,Anne Tjønneland,Françoise Clavel-Chapelon,D T Bishop,Mark Teo,Margaret A. Knowles,Simonetta Guarrera,Silvia Polidoro,Fulvio Ricceri,Carlotta Sacerdote,Alessandra Allione,Geraldine Cancel-Tassin,Silvia Selinski,Jan G. Hengstler,Holger Dietrich,Tony Fletcher,Peter Rudnai,Eugen Gurzau,Kvetoslava Koppova,Sophia C.E. Bolick,Ashley C. Godfrey,Zongli Xu,José I Sanz-Velez,Maria D. Garcia-Prats,Manuel Sanchez,Gabriel Valdivia,Stefano Porru,Simone Benhamou,Simone Benhamou,Robert N. Hoover,Joseph F. Fraumeni,Debra T. Silverman,Stephen J. Chanock +113 more
TL;DR: Two new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1 are identified and previous candidate associations for the GSTM1 deletion and a tag SNP for NAT2 acetylation status are validated, and interactions with smoking in both regions are found.
Journal ArticleDOI
Sequence Variant on 8q24 Confers Susceptibility to Urinary Bladder Cancer
Lambertus A. Kiemeney,Steinunn Thorlacius,Patrick Sulem,Frank Geller,Katja K H Aben,Simon N. Stacey,Julius Gudmundsson,Margret Jakobsdottir,Jon Thor Bergthorsson,Asgeir Sigurdsson,Thorarinn Blondal,J. Alfred Witjes,Sita H. Vermeulen,Christina A. Hulsbergen-van de Kaa,Dorine W. Swinkels,Martine Ploeg,Erik B. Cornel,Henk Vergunst,Thorgeir E. Thorgeirsson,Daniel F. Gudbjartsson,Sigurjon A. Gudjonsson,Gudmar Thorleifsson,Kari T. Kristinsson,Magali Mouy,Steinunn Snorradottir,Donatella Placidi,Marcello Campagna,Cecilia Arici,Kvetoslava Koppova,Eugene Gurzau,Peter Rudnai,Eliane Kellen,Silvia Polidoro,Simonetta Guarrera,Carlotta Sacerdote,Manuel Sanchez,Berta Saez,Gabriel Valdivia,Charlotta Ryk,Petra J. de Verdier,Annika Lindblom,Klaus Golka,D. Timothy Bishop,Margaret A. Knowles,Sigfus Nikulasson,Vigdis Petursdottir,Eirikur Jonsson,Gudmundur Geirsson,Baldvin Kristjansson,Jose I. Mayordomo,Gunnar Steineck,Stefano Porru,Frank Buntinx,Frank Buntinx,Maurice P. Zeegers,Maurice P. Zeegers,Tony Fletcher,Rajesh Kumar,Giuseppe Matullo,Paolo Vineis,Anne E. Kiltie,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +67 more
TL;DR: No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers.
Journal ArticleDOI
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.
Fonnet E. Bleeker,Simona Lamba,Sieger Leenstra,Dirk Troost,Theo J. M. Hulsebos,W. Peter Vandertop,W. Peter Vandertop,Milo Frattini,Francesca Molinari,Margaret A. Knowles,Aniello Cerrato,Monica Rodolfo,Aldo Scarpa,Lara Felicioni,Fiamma Buttitta,Sara Malatesta,Antonio Marchetti,Alberto Bardelli +17 more
TL;DR: In this paper, the authors search for mutations at position R132 of the IDH1 gene in a panel of 672 tumor samples, including high-grade glioma, gastrointestinal stromal tumors (GIST), melanoma, bladder, breast, colorectal, lung, ovarian, pancreas, prostate, and thyroid carcinoma specimens.