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Angel M. Carrión
Researcher at Pablo de Olavide University
Publications - 49
Citations - 2688
Angel M. Carrión is an academic researcher from Pablo de Olavide University. The author has contributed to research in topics: Dynorphin & Memory consolidation. The author has an hindex of 26, co-authored 49 publications receiving 2405 citations. Previous affiliations of Angel M. Carrión include Spanish National Research Council.
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DREAM is a Ca2+-regulated transcriptional repressor.
TL;DR: DREAM is the first known Ca2+-binding protein to function as a DNA-binding transcriptional regulator and represses transcription from the early response gene c-fos.
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Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor
Ángela Fontán-Lozano,José Luis Sáez-Cassanelli,Mari Carmen Inda,Mercedes de los Santos-Arteaga,Sergio Antonio Sierra-Domínguez,Guillermo López-Lluch,José M. Delgado-García,Angel M. Carrión +7 more
TL;DR: The effects of maintaining mature mice on a long-term intermittent fasting diet (L-IFD) are found to enhance learning and consolidation processes and to provide a molecular and cellular mechanism by which L-IFd may enhance cognition, ameliorating some aging-associated cognitive deficits.
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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome
Elísabet Alcocer-Gómez,Cristina Ulecia-Morón,Fabiola Marín-Aguilar,Tatyana Rybkina,Nieves Casas-Barquero,Jesús Ruiz-Cabello,Bernhard Ryffel,Lionel Apetoh,Lionel Apetoh,François Ghiringhelli,François Ghiringhelli,Pedro Bullón,José Antonio Sánchez-Alcázar,Angel M. Carrión,Mario D. Cordero +14 more
TL;DR: It is shown that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis, and the inflammaome could be a target for new therapeutic interventions to prevent depression in patients.
Journal ArticleDOI
Molecular bases of caloric restriction regulation of neuronal synaptic plasticity.
Ángela Fontán-Lozano,Guillermo López-Lluch,José M. Delgado-García,Plácido Navas,Angel M. Carrión +4 more
TL;DR: The effect of CR is presented and discussed in synaptic processes underlying analgesia and cognitive improvement in healthy, sick, and aging animals and the possible role of mitochondrial biogenesis induced by CR in regulation of neuronal synaptic plasticity is discussed.
Journal ArticleDOI
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.
Ángela Fontán-Lozano,Rocío Romero-Granados,Julieta Troncoso,Julieta Troncoso,Alejandro Múnera,Alejandro Múnera,José M. Delgado-García,Angel M. Carrión +7 more
TL;DR: Systemic treatment with HDAC inhibitors improved cognitive processes in EBCC and in ORM tests and pointed outHDAC inhibitors as candidate agents for the palliative treatment of learning and memory impairments in aging and in neurodegenerative disorders.