L
Lionel Apetoh
Researcher at French Institute of Health and Medical Research
Publications - 110
Citations - 24045
Lionel Apetoh is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 53, co-authored 101 publications receiving 19487 citations. Previous affiliations of Lionel Apetoh include University of Burgundy & University of Paris-Sud.
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Journal ArticleDOI
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Lionel Apetoh,François Ghiringhelli,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Michel Obeid,Michel Obeid,Michel Obeid,Carla Ortiz,Carla Ortiz,Carla Ortiz,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,M. Chiara Maiuri,Evelyn Ullrich,Evelyn Ullrich,Evelyn Ullrich,Patrick Saulnier,Huan Yang,Sebastian Amigorena,Bernard Ryffel,Franck J. Barrat,Paul Saftig,Francis Lévi,Francis Lévi,Rosette Lidereau,Catherine Noguès,Jean-Paul Mira,Agnès Chompret,Virginie Joulin,Françoise Clavel-Chapelon,Jean Bourhis,Fabrice Andre,Suzette Delaloge,T. Tursz,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +42 more
TL;DR: A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described.
Journal ArticleDOI
Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,François Ghiringhelli,François Ghiringhelli,François Ghiringhelli,Gian Maria Fimia,Lionel Apetoh,Lionel Apetoh,Lionel Apetoh,Jean-Luc Perfettini,Jean-Luc Perfettini,Jean-Luc Perfettini,Maria Castedo,Maria Castedo,Maria Castedo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,Theoharis Panaretakis,Theoharis Panaretakis,Theoharis Panaretakis,Noelia Casares,Noelia Casares,Noelia Casares,Didier Métivier,Didier Métivier,Didier Métivier,Nathanael Larochette,Nathanael Larochette,Nathanael Larochette,Peter van Endert,Peter van Endert,Fabiola Ciccosanti,Mauro Piacentini,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer,Guido Kroemer,Guido Kroemer +41 more
TL;DR: It is shown that anthracyclin-induced CRT translocation induces the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and is identified as a key feature determining anticancer immune responses.
Journal ArticleDOI
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
François Ghiringhelli,Lionel Apetoh,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Laetitia Aymeric,Laetitia Aymeric,Laetitia Aymeric,Yuting Ma,Yuting Ma,Yuting Ma,Carla Ortiz,Karim Vermaelen,Theocharis Panaretakis,Theocharis Panaretakis,Theocharis Panaretakis,Grégoire Mignot,Evelyn Ullrich,Evelyn Ullrich,Evelyn Ullrich,Jean-Luc Perfettini,Jean-Luc Perfettini,Jean-Luc Perfettini,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Ezgi Tasdemir,Ezgi Tasdemir,Ezgi Tasdemir,Martin Uhl,Pierre Génin,Ahmet Civas,Bernhard Ryffel,Jean Kanellopoulos,Jürg Tschopp,Fabrice Andre,Fabrice Andre,Fabrice Andre,Rosette Lidereau,Nicole McLaughlin,Nicole M. Haynes,Mark J. Smyth,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +45 more
TL;DR: It is shown that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1 β (IL-1β).
Journal ArticleDOI
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Sophie Viaud,Sophie Viaud,Fabiana Saccheri,Grégoire Mignot,Takahiro Yamazaki,Romain Daillère,Romain Daillère,Dalil Hannani,David Enot,David Enot,Christina Pfirschke,Camilla Engblom,Mikael J. Pittet,Andreas Schlitzer,Florent Ginhoux,Lionel Apetoh,Elisabeth Chachaty,Paul Louis Woerther,Gérard Eberl,Marion Bérard,Chantal Ecobichon,Chantal Ecobichon,Dominique Clermont,Chantal Bizet,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Paule Opolon,Nadia Yessaad,Eric Vivier,Bernhard Ryffel,Charles O. Elson,Joël Doré,Joël Doré,Guido Kroemer,Patricia Lepage,Patricia Lepage,Ivo G. Boneca,Ivo G. Boneca,François Ghiringhelli,François Ghiringhelli,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel +44 more
TL;DR: It is demonstrated that cyclophosphamide alters the composition of microbiota in the small intestine and induces the translocation of selected species of Gram-positive bacteria into secondary lymphoid organs, which suggests that the gut microbiota help shape the anticancer immune response.
Journal ArticleDOI
Immunological aspects of cancer chemotherapy.
Laurence Zitvogel,Lionel Apetoh,Lionel Apetoh,François Ghiringhelli,Guido Kroemer,Guido Kroemer +5 more
TL;DR: It is proposed that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.