Angela Wadham

TL;DR: Adherence to all four recommended drugs was greater among fixed dose combination than usual care participants at 12 months and there was no statistically significant improvement in risk factor control between the fixed doses and usual care groups over 12 months.

TL;DR: The specific home-based binocular falling-blocks video game used in this clinical trial did not improve visual outcomes more than the placebo video game despite increases in fellow eye contrast during game play.

TL;DR: Polypill therapy significantly improved adherence, SBP and LDL-cholesterol in high risk patients compared with usual care, especially among those who were under-treated at baseline.

TL;DR: The ONgoing Telmisartan alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) showed that the angiotensin receptor blocker telmisARTan 80 mg was not inferior to the angioensin-converting enzyme inhibitor ramipril 10 mg, and the combination no more effective than RAMPril alone, in decreasing morbidity and mortality in patients with cardiovascular disease or high-risk diabetes as discussed by the authors.

TL;DR: This open-label randomised controlled trial comparing a once-daily polypill containing four preventive medications with usual care to assess whether a medication strategy using a fixed dose combination pill ('polypill') could improve prescribing and adherence to recommended medications, lower blood pressure and improve lipids compared with current care over 12 months.