S
Simon Thom
Researcher at National Institutes of Health
Publications - 77
Citations - 4997
Simon Thom is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Polypill. The author has an hindex of 29, co-authored 76 publications receiving 3852 citations. Previous affiliations of Simon Thom include Aarhus University & Gloucestershire Hospitals NHS Foundation Trust.
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Journal ArticleDOI
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola Del Greco M,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan James,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher P. Nelson,Teemu J. Niiranen,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Aarno Palotie,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,Daniel I. Chasman,David Conen,David Conen,Francesco Cucca,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Christopher Newton-Cheh,Morris J. Brown,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +341 more
TL;DR: In this article, the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry was conducted.
Journal ArticleDOI
Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.
Rasha Al-Lamee,Rasha Al-Lamee,David Thompson,David Thompson,Hakim-Moulay Dehbi,Sayan Sen,Sayan Sen,Kare Tang,John R. Davies,Thomas R. Keeble,Michael Mielewczik,Raffi Kaprielian,Iqbal S. Malik,Sukhjinder Nijjer,Ricardo Petraco,Ricardo Petraco,Christopher Cook,Christopher Cook,Yousif Ahmad,Yousif Ahmad,James P. Howard,James P. Howard,Christopher S. Baker,Andrew Sharp,Robert Gerber,Suneel Talwar,Ravi Assomull,Jamil Mayet,Jamil Mayet,Roland Wensel,David Collier,Matthew J. Shun-Shin,Matthew J. Shun-Shin,Simon Thom,Simon Thom,Justin E. Davies,Justin E. Davies,Darrel P. Francis,Darrel P. Francis,Amarjit Sethi,Punit Ramrakha,Rodney A. Foale,Ramzi Khamis,Nearchos Hadjiloizou,Masood Khan,Jaspal S. Kooner,Michael Bellamy,Ghada W. Mikhail,Piers Clifford,Peter O'Kane,Terry Levy,Rosie Swallow +51 more
TL;DR: In patients with medically treated angina and severe coronary stenosis, PCI did not increase exercise time by more than the effect of a placebo procedure, and the primary endpoint was difference in exercise time increment between groups.
Journal ArticleDOI
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Fotios Drenos,Marie Loh,Marie Loh,Niek Verweij,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Bernard Keavney,Bernard Keavney,Maciej Tomaszewski,Maciej Tomaszewski,Nilesh J. Samani,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Patricia B. Munroe,Georg Ehret,Georg Ehret,Louise V. Wain +74 more
TL;DR: In this paper, the authors report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci.
Journal ArticleDOI
Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD: The UMPIRE Randomized Clinical Trial
Simon Thom,Neil Poulter,Jane Field,Anushka Patel,Dorairaj Prabhakaran,Alice Stanton,Diederick E. Grobbee,Michiel L. Bots,K. Srinath Reddy,Raghu Cidambi,Severine Bompoint,Laurent Billot,Anthony Rodgers +12 more
TL;DR: There was consistency of effects across predefined subgroups, and evidence existed of larger benefits in patients with lower adherence at baseline, which resulted in significantly improved medication adherence at the end of the study.
Journal ArticleDOI
An international randomised placebo-controlled trial of a four-component combination pill ("polypill") in people with raised cardiovascular risk.
Anthony Rodgers,Anushka Patel,Otavio Berwanger,M. L. Bots,Richard H. Grimm,D. E. Grobbee,Rod Jackson,Bruce Neal,James D. Neaton,Neil R Poulter,Natasha Rafter,P. K. Raju,Srinath Reddy,Simon Thom,S. Vander Hoorn,Ruth Webster +15 more
TL;DR: This polypill achieved sizeable reductions in SBP and LDL-cholesterol but caused side effects in about 1 in 6 people, the halving in predicted cardiovascular risk is moderately lower than previous estimates and the side effect rate is moderately higher.