Angelo J. M. Lubag

TL;DR: This review describes examples of imaging extracellular pH in brain tumors, ischemic hearts, and pancreatic islets with Gd(3+)-based pH sensors and discusses the potential of CEST and PARACEST agents as metabolic imaging sensors.

TL;DR: Exchange rates derived from omega plots using either high‐resolution CEST NMR data or CEST data obtained by imaging agree favorably with exchange rates measured by the more commonly used Bloch fitting and line‐width methods, potentially allowing access to a direct measure of exchange rates in vivo, where the agent concentration is typically unknown.

TL;DR: The properties of a novel Gd(3+)-based MRI zinc sensor are reported and it is shown to have a relatively strong binding affinity for Zn(2+) (K(D) = 33.6 nM), similar to the affinity of the Zn (2+) ion with HSA alone.

TL;DR: It is demonstrated here that divalent zinc ions coreleased with insulin from β-cells in response to high glucose are readily detected by MRI using the Zn2+-responsive T1 agent, GdDOTA-diBPEN, which offers the exciting potential for deep-tissue monitoring of β-cell function in vivo during development of type 2 diabetes or after implantation of islets in type I diabetic patients.

TL;DR: Results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.