R
Robert E. Lenkinski
Researcher at University of Texas Southwestern Medical Center
Publications - 323
Citations - 17015
Robert E. Lenkinski is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Magnetic resonance imaging & Proton NMR. The author has an hindex of 66, co-authored 321 publications receiving 15743 citations. Previous affiliations of Robert E. Lenkinski include Medrad Inc. & Harvard University.
Papers
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Journal ArticleDOI
Lactate Metabolism in Human Lung Tumors
Brandon Faubert,Kevin Y. Li,Ling Cai,Christopher T. Hensley,Jiyeon Kim,Lauren G. Zacharias,Chendong Yang,Quyen N. Do,Sarah Doucette,Daniel Burguete,Hong Li,Giselle Huet,Qing Yuan,Trevor Wigal,Yasmeen M. Butt,Min Ni,Jose R. Torrealba,Dwight H Oliver,Robert E. Lenkinski,Craig R. Malloy,Jason W Wachsmann,Jamey D. Young,Kemp H. Kernstine,Ralph J. DeBerardinis +23 more
TL;DR: The data indicate that tumors, including bona fide human NSCLC, can use lactate as a fuel in vivo, and directly comparing lactate and glucose metabolism in vivo indicated that lactate's contribution to the TCA cycle predominates.
Journal ArticleDOI
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley,Brandon Faubert,Qing Yuan,Naama Lev-Cohain,Eunsook S. Jin,Jiyeon Kim,Lei Jiang,Bookyung Ko,Rachael Skelton,Laurin Loudat,Michelle Wodzak,Claire Klimko,Elizabeth A. McMillan,Yasmeen M. Butt,Min Ni,Dwight H Oliver,Jose R. Torrealba,Craig R. Malloy,Kemp H. Kernstine,Robert E. Lenkinski,Ralph J. DeBerardinis +20 more
TL;DR: These findings not only demonstrate the heterogeneity in tumor metabolism in vivo but also highlight the strong influence of the microenvironment on this feature.
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Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.
Donna M. Mancini,Glenn A. Walter,Nathaniel Reichek,Robert E. Lenkinski,Kevin K. McCully,James L. Mullen,John R. Wilson +6 more
TL;DR: Findings indicate that patients with chronic HF frequently develop significant skeletal muscle atrophy and metabolic abnormalities, which is consistent with intrinsic oxidative abnormalities.
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PARACEST agents: modulating MRI contrast via water proton exchange
TL;DR: The goal of this article is to review the factors that govern water molecule and water proton exchange in gadolinium (III) complexes and to compare the potential sensitivity of PARACEST agents versus Gd(3+)-based T(1) relaxation agents for altering tissue contrast.
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In vivo near-infrared fluorescence imaging of osteoblastic activity
Atif Zaheer,Robert E. Lenkinski,Ashfaq Mahmood,Alun G. Jones,Lewis C. Cantley,John V. Frangioni +5 more
TL;DR: A near-infrared (NIR) fluorescent bisphosphonate derivative is synthesized that exhibits rapid and specific binding to HA in vitro and in vivo and can be used to study skeletal development, osteoblastic metastasis, coronary atherosclerosis, and other human diseases.