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Angelo J. M. Lubag
Researcher at University of Texas Southwestern Medical Center
Publications - 16
Citations - 1181
Angelo J. M. Lubag is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: In vivo & Molecular sieve. The author has an hindex of 14, co-authored 16 publications receiving 1083 citations. Previous affiliations of Angelo J. M. Lubag include University of Texas at Dallas.
Papers
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Journal ArticleDOI
Responsive MRI Agents for Sensing Metabolism in Vivo
Luis M. De León-Rodríguez,Angelo J. M. Lubag,Craig R. Malloy,Gary V. Martinez,Gary V. Martinez,Robert J. Gillies,Robert J. Gillies,A. Dean Sherry +7 more
TL;DR: This review describes examples of imaging extracellular pH in brain tumors, ischemic hearts, and pancreatic islets with Gd(3+)-based pH sensors and discusses the potential of CEST and PARACEST agents as metabolic imaging sensors.
Journal ArticleDOI
A concentration-independent method to measure exchange rates in PARACEST agents.
W. Thomas Dixon,Jimin Ren,Angelo J. M. Lubag,S. James Ratnakar,Elena Vinogradov,Ileana Hancu,Robert E. Lenkinski,A. Dean Sherry,A. Dean Sherry +8 more
TL;DR: Exchange rates derived from omega plots using either high‐resolution CEST NMR data or CEST data obtained by imaging agree favorably with exchange rates measured by the more commonly used Bloch fitting and line‐width methods, potentially allowing access to a direct measure of exchange rates in vivo, where the agent concentration is typically unknown.
Journal ArticleDOI
A new gadolinium-based MRI zinc sensor.
Ana Cristina Esqueda,Jorge A. López,Gabriel Andreu-de-Riquer,José C. Alvarado-Monzón,S. James Ratnakar,Angelo J. M. Lubag,A. Dean Sherry,Luis M. De León-Rodríguez +7 more
TL;DR: The properties of a novel Gd(3+)-based MRI zinc sensor are reported and it is shown to have a relatively strong binding affinity for Zn(2+) (K(D) = 33.6 nM), similar to the affinity of the Zn (2+) ion with HSA alone.
Journal ArticleDOI
Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent.
Angelo J. M. Lubag,Luis M. De León-Rodríguez,Luis M. De León-Rodríguez,Shawn C. Burgess,A. Dean Sherry +4 more
TL;DR: It is demonstrated here that divalent zinc ions coreleased with insulin from β-cells in response to high glucose are readily detected by MRI using the Zn2+-responsive T1 agent, GdDOTA-diBPEN, which offers the exciting potential for deep-tissue monitoring of β-cell function in vivo during development of type 2 diabetes or after implantation of islets in type I diabetic patients.
Journal ArticleDOI
Modulation of Water Exchange in Europium(III) DOTA−Tetraamide Complexes via Electronic Substituent Effects
TL;DR: Results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.