A
Angie Cheng
Researcher at Woodward, Inc.
Publications - 12
Citations - 4555
Angie Cheng is an academic researcher from Woodward, Inc.. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 4, co-authored 12 publications receiving 4421 citations.
Papers
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Journal ArticleDOI
RAS Is Regulated by the let-7 MicroRNA Family
Steven M. Johnson,Helge Grosshans,Jaclyn Shingara,Mike Byrom,Rich Jarvis,Angie Cheng,Emmanuel Labourier,Kristy L. Reinert,David Brown,Frank J. Slack +9 more
TL;DR: It is shown that the let-7 family negatively regulates let-60/RAS, a regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer.
Journal ArticleDOI
The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
Aurora Esquela-Kerscher,Phong Trang,Jason F. Wiggins,Lubna Patrawala,Angie Cheng,Lance P. Ford,Joanne B. Weidhaas,David F.M. Brown,Andreas G. Bader,Frank J. Slack +9 more
TL;DR: In this paper, the authors used both in vitro and in vivo approaches to show that the let-7 microRNA directly represses cancer growth in the lung and indicated that this miRNA may be useful as a novel therapeutic agent in lung cancer.
Patent
Methods and compositions involving mirna and mirna inhibitor molecules
David Brown,Lance P. Ford,Angie Cheng,Rich Jarvis,Mike Byrom,Dmitriy Ovcharenko,Eric Devroe,Kevin Kelnar +7 more
TL;DR: In this paper, the authors present methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules and identify miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications.
Patent
Methods and compositions involving mirna and mirna inhibitormolecules
Angie Cheng,Rich Jarvis,Lance P. Ford,David Brown,Eric Devroe,Kevin Kelnar,Dmitriy Ovcharenko,Mike Byrom +7 more
Patent
METHOD AND COMPOSITION RELATED TO miRNA AND miRNA INHIBITORY MOLECULE
David Brown,Mike Byrom,Angie Cheng,Eric Devroe,Lance P. Ford,Rich Jarvis,Kevin Kelnar,Dmitriy Ovcharenko,ドミトリ オブチャレンコ,ケビン ケルナー,リッチ ジャービス,アンジー チェン,エリック デヴロエ,マイク バイロム,ランス フォード,デイビッド ブラウン +15 more
TL;DR: In this article, the authors provided methods and compositions for identifying the miRNAs having specific cellular functions related to therapeutic, diagnostic and prognostic applications wherein, synthetic miRNA and/or miRNA inhibitors are used in library screening assays.