Woodward, Inc.

About: Woodward, Inc. is a company organization based out in Fort Collins, Colorado, United States. It is known for research contribution in the topics: Combustion chamber & Combustion. The organization has 1876 authors who have published 1905 publications receiving 51559 citations. The organization is also known as: Woodward, Inc. & Woodward (United States).

Nonlinear Analysis of Stress and Strain in Soils

Abstract: A simple, practical procedure for representing the nonlinear, stress-dependent, inelastic stress-strain behavior of soils was developed. The values of the required parameters employed in the stress-strain relationship may be derived from the results of standard triaxial tests on plane strain compression tests involving primary loading, unloading, and reloading. Comparisons of calculated and measured strains in specimens of dense and loose silica sand showed that the relationship was capable of accurately representing the behavior of this sand under complex triaxial loading conditions, and analyses of the behavior of footings on sand and clay showed that finite element stress analyses conducted using this relationship were in good agreement with empirical observations and applicable theories.

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis.

Abstract: Of the over 200 identified mammalian microRNAs (miRNAs), only a few have known biological activity. To gain a better understanding of the role that miRNAs play in specific cellular pathways, we utilized antisense molecules to inhibit miRNA activity. We used miRNA inhibitors targeting miR-23, 21, 15a, 16 and 19a to test efficacy of antisense molecules in reducing miRNA activity on reporter genes bearing miRNAbinding sites. The miRNA inhibitors de-repressed reporter gene activity when a miRNA-binding site was cloned into its 3 0 -untranslated region. We employed a library of miRNA inhibitors to screen for miRNA involved in cell growth and apoptosis. In HeLa cells, we found that inhibition of miR-95, 124, 125, 133, 134, 144, 150, 152, 187, 190, 191, 192, 193, 204, 211, 218, 220, 296 and 299 caused a decrease in cell growth and that inhibition of miR-21 and miR-24 had a profound increase in cell growth. On the other hand, inhibition of miR-7, 19a, 23, 24, 134, 140, 150, 192 and 193 downregulated cell growth, and miR-107, 132, 155, 181, 191, 194, 203, 215 and 301 increased cell growth in lung carcinoma cells, A549. We also identified miRNA that when inhibited increased the level of apoptosis (miR1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. From these screens, we conclude that miRNA-mediated regulation has a complexity of cellular outcomes and that miRNAs can be mediators of regulation of cell growth and apoptosis pathways.

Modification of Empirical Strong Ground Motion Attenuation Relations to Include the Amplitude and Duration Effects of Rupture Directivity

Abstract: Rupture directivity effects cause spatial variations in ground motion amplitude and duration around faults and cause differences between the strike-normal and strike-parallel components of horizontal ground motion amplitudes, which also have spatial variation around the fault. These variations become significant at a period of 0.6 second and generally grow in size with increasing period. We have developed modifications to empirical strong ground motion attenuation relations to account for the effects of rupture directivity on strong motion amplitudes and durations. The modifications are based on an empirical analysis of near-fault data. The ground motion parameters that are modified include the average horizontal response spectral acceleration, the duration of the acceleration time history, and the ratio of strike-normal to strike-parallel spectral acceleration. The parameters upon which the adjustments to average horizontal amplitude and duration depend are the fraction of the fault rupture that occurs on the part of the fault that lies between the hypocenter and the site, and the angle between the fault plane and the path from the hypocenter to the site. Since both of these parameters can be derived from the hypocenter location and the fault geometry, the model of rupture directivity effects on ground motions that we have developed can be directly included in probabilistic seismic hazard calculations. The spectral acceleration is larger for periods longer than 0.6 second, and the duration is smaller, when rupture propagates toward a site. For sites located close to faults, the strike-normal spectral acceleration is larger than the strike-parallel spectral acceleration at periods longer than 0.6 second in a manner that depends on magnitude, distance, and angle. To facilitate the selection of time histories that represent near-fault ground motion conditions in an appropriate manner, we provide a list of near-fault records indicating the rupture directivity parameters that each contains.

Simulating seismic wave propagation in 3D elastic media using staggered-grid finite differences

Abstract: This article provides an overview of the application of the staggered-grid finite-difference technique to model wave propagation problems in 3D elastic media. In addition to presenting generalized, discrete representations of the differential equations of motion using the staggered-grid approach, we also provide detailed formulations that describe the incorporation of moment-tensor sources, the implementation of a stable and accurate representation of a planar free-surface boundary for 3D models, and the derivation and implementation of an approximate technique to model spatially variable anelastic attenuation within time-domain finite-difference computations. The comparison of results obtained using the staggered-grid technique with those obtained using a frequency-wavenumber algorithm shows excellent agreement between the two methods for a variety of models. In addition, this article also introduces a memory optimization procedure that allows large-scale 3D finite-difference problems to be computed on a conventional, single-processor desktop workstation. With this technique, model storage is accommodated using both external (hard-disk) and internal (core) memory. To reduce system overhead, a cascaded time update procedure is utilized to maximize the number of computations performed between I/O operations. This formulation greatly expands the applicability of the 3D finite-difference technique by providing an efficient and practical algorithm for implementation on commonly available workstation platforms.