Anguo Li

TL;DR: The first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo Nir-II osteosarcoma imaging and excellent photothermal efficiency are presented.

TL;DR: Quaternary ammonium salts Q8PBn and Q8PNap as a novel class of bright near infrared window II (NIR-II, 1,000 - 1,700 nm) probes were designed and synthesized, and the twisted intramolecular charge transfer (TICT) formation at the excited state can be effectively suppressed for the newly designed probes.

TL;DR: Two homologous types of fluorescent probes CH1055‐PEG‐PT and CH10 55‐Peg‐Affibody, which show highly promising results for targeting imaging of osteosarcoma and its lung metastasis, respectively, are designed and synthesized and found to be far superior to that of computed tomography for the early in vivo 143B tumor imaging.

TL;DR: A novel NIR-II small-molecule probe H4–PEG-Glu with a thiopyrylium cation that can quickly and effectively image mitochondria in acute myeloid leukemia (AML) cells, and exhibit moderate cytotoxicity against AML cancer cells in a dose dependent-manner without laser irradiation is synthesized.

TL;DR: Results indicated that the cartilage-targeting probe CH1055-WL allowed visual monitoring of AC degeneration in living subjects, thus displaying promise for early OA detection.