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Angus Scrimgeour
Researcher at University of Virginia
Publications - 7
Citations - 2677
Angus Scrimgeour is an academic researcher from University of Virginia. The author has contributed to research in topics: Glycogen synthase & Glycogen. The author has an hindex of 5, co-authored 7 publications receiving 2476 citations.
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Journal ArticleDOI
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Sue C. Bodine,Trevor Stitt,Michael Gonzalez,William O. Kline,Gretchen L. Stover,Roy Bauerlein,Elizabeth Zlotchenko,Angus Scrimgeour,John C. Lawrence,David J. Glass,George D. Yancopoulos +10 more
TL;DR: It is concluded that the activation of the Akt/mTOR pathway and its downstream targets, p70S6K and PHAS-1/4E-BP1, is requisitely involved in regulating skeletal muscle fibre size, and that activation of this pathway can oppose muscle atrophy induced by disuse.
Journal ArticleDOI
Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.
Yoichi Suzuki,Carita Lanner,Jong-Hwa Kim,Pier Giuseppe Vilardo,Hong Zhang,Jie Yang,Lori D. Cooper,Marcella Steele,Andrew Kennedy,Cheryl B. Bock,Angus Scrimgeour,John C. Lawrence,Anna A. DePaoli-Roach +12 more
TL;DR: It is demonstrated that RGL is genetically linked to glycogen metabolism, since its loss decreases PP1 and basal GS activities and glycogen accumulation.
Journal ArticleDOI
Effect of glycogen synthase overexpression on insulin-stimulated muscle glucose uptake and storage
Donovan L. Fogt,Shujia Pan,Sukho Lee,Zhenping Ding,Angus Scrimgeour,John C. Lawrence,John L. Ivy +6 more
TL;DR: Results indicate that glycogen synthase activity is not rate limiting for insulin-stimulated glucose uptake in skeletal muscle and that the inverse relationship between muscle glycogen and insulin- stimulated glucose uptake is an association, not a cause and effect relationship.
Journal ArticleDOI
Inhibitor-1 Is Not Required for the Activation of Glycogen Synthase by Insulin in Skeletal Muscle
TL;DR: Insulin increased glycogen synthase activity and the synthesis of glycogen to the same extent in wild-type and knockout mice, indicating that neither Inhibitor-1 nor DARPP-32 is required for the full stimulatory effects of insulin on glycogens synthase and glycogen synthesis in skeletal muscle.