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Anjali K. Nath
Researcher at Beth Israel Deaconess Medical Center
Publications - 40
Citations - 3984
Anjali K. Nath is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Cyanide & Medicine. The author has an hindex of 20, co-authored 34 publications receiving 3732 citations. Previous affiliations of Anjali K. Nath include Yale University & Broad Institute.
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Journal ArticleDOI
Biological Action of Leptin as an Angiogenic Factor
M. Rocio Sierra-Honigmann,Anjali K. Nath,Chiaki Murakami,Guillermo García-Cardeña,Andreas Papapetropoulos,William C. Sessa,Lisa A. Madge,Jeffrey S. Schechner,Michael B. Schwabb,Peter J. Polverini,Jaime Flores-Riveros +10 more
TL;DR: It is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells, indicating that the vascular endothelium is a target for leptin and suggesting a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.
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Control of apoptosis during angiogenesis by survivin expression in endothelial cells.
Daniel S. O'Connor,Jeffrey S. Schechner,Colette Adida,Mehdi Mesri,Annette L. Rothermel,Fengzhi Li,Anjali K. Nath,Jordan S. Pober,Dario C. Altieri +8 more
TL;DR: Findings identify survivin as a novel growth factor-inducible protective gene expressed by endothelial cells during angiogenesis, which Therapeutic manipulation of survivin expression and function in endothelium may influence compensatory or pathological (tumor)Angiogenesis.
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In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse.
Jeffrey S. Schechner,Anjali K. Nath,L. Zheng,Martin S. Kluger,Christopher C.W. Hughes,M. R. Sierra-Honigmann,Marc I. Lorber,George Tellides,Michael Kashgarian,Alfred L. M. Bothwell,Jordan S. Pober +10 more
TL;DR: This system provides an in vivo model for dissecting mechanisms of microvascular remodeling by using genetically modified endothelium and incorporation of such human endothelial-lined microvessels into engineered synthetic skin may improve graft viability, especially in recipients with impaired angiogenesis.
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A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
Frank J. Giordano,Hans-Peter Gerber,Simon-Peter Williams,Nicholas VanBruggen,Stuart Bunting,Pilar Ruiz-Lozano,Yusu Gu,Anjali K. Nath,Yan Huang,Reed Hickey,Nancy D. Dalton,Kirk L. Peterson,John Ross,Kenneth R. Chien,Napoleone Ferrara +14 more
TL;DR: These findings establish the critical importance of cardiac myocyte-derived vascular endothelial growth factor in cardiac morphogenesis and determination of heart function and establish an adult murine model of hypovascular nonnecrotic cardiac contractile dysfunction.
Journal ArticleDOI
Induction of angiogenesis in a mouse model using engineered transcription factors.
Edward J. Rebar,Yan Huang,Reed Hickey,Anjali K. Nath,David F. Meoli,Sameer K. Nath,Bingliang Chen,Lei Xu,Yuxin Liang,Andrew C. Jamieson,Lei Zhang,S. Kaye Spratt,Casey C. Case,Alan P. Wolffe,Frank J. Giordano +14 more
TL;DR: These data establish, for the first time, that specifically designed transcription factors can regulate an endogenous gene in vivo and evoke a potentially therapeutic biophysiologic effect.