E
Edward J. Rebar
Researcher at Sangamo BioSciences
Publications - 152
Citations - 24248
Edward J. Rebar is an academic researcher from Sangamo BioSciences. The author has contributed to research in topics: Zinc finger & Zinc finger nuclease. The author has an hindex of 58, co-authored 150 publications receiving 22443 citations. Previous affiliations of Edward J. Rebar include University of Texas at Austin.
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Journal ArticleDOI
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller,Siyuan Tan,Guijuan Qiao,Kyle A. Barlow,Jianbin Wang,Danny F Xia,Xiangdong Meng,David Paschon,Elo Leung,Sarah J. Hinkley,Gladys P Dulay,Kevin Hua,Irina Ankoudinova,Gregory J. Cost,Fyodor D. Urnov,H. Steve Zhang,Michael C. Holmes,Lei Zhang,Philip D. Gregory,Edward J. Rebar +19 more
TL;DR: This study identifies TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and uses them to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%.
Journal ArticleDOI
Genome editing with engineered zinc finger nucleases
TL;DR: A broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent repair.
Journal ArticleDOI
Genetic engineering of human pluripotent cells using TALE nucleases
Dirk Hockemeyer,Haoyi Wang,Samira Kiani,Christine S. Lai,Qing Gao,John P. Cassady,Gregory J. Cost,Lei Zhang,Yolanda Santiago,Jeffrey C. Miller,Bryan Zeitler,Jennifer M. Cherone,Xiangdong Meng,Sarah J. Hinkley,Edward J. Rebar,Philip D. Gregory,Fyodor D. Urnov,Rudolf Jaenisch +17 more
TL;DR: In this article, the authors used transcription activator-like effector nucleases (TALENs) for site-specific genome modification in human pluripotent cells with similar efficiency and precision as do zinc-finger nucleases.
Journal ArticleDOI
An improved zinc-finger nuclease architecture for highly specific genome editing
Jeffrey C. Miller,Michael C. Holmes,Jianbin Wang,Dmitry Guschin,Ya-Li Lee,Igor Rupniewski,Christian Beauséjour,Christian Beauséjour,Adam James Waite,Nathaniel Wang,Kenneth Kim,Philip D. Gregory,Carl O. Pabo,Carl O. Pabo,Edward J. Rebar +14 more
TL;DR: Using structure-based design, two variant ZFNs are engineer that modify a native endogenous locus as efficiently as the parental architecture, but with a >40-fold reduction in homodimer function and much lower levels of genome-wide cleavage.
Journal ArticleDOI
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Elena E. Perez,Jianbin Wang,Jeffrey C. Miller,Yann Jouvenot,Yann Jouvenot,Kenneth Kim,Olga Liu,Nathaniel Wang,Gary Lee,Victor Bartsevich,Ya Li Lee,Dmitry Guschin,Igor Rupniewski,Adam James Waite,Carmine Carpenito,Richard G. Carroll,Jordan S. Orange,Fyodor D. Urnov,Edward J. Rebar,Dale Ando,Philip D. Gregory,James L. Riley,Michael C. Holmes,Carl H. June +23 more
TL;DR: O adoptive transfer of ex vivo expanded CCR5 ZFN–modified autologous CD4+ T cells in HIV patients is an attractive approach for the treatment of HIV-1 infection.