C
Christopher C.W. Hughes
Researcher at University of California, Irvine
Publications - 159
Citations - 16089
Christopher C.W. Hughes is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Angiogenesis & T cell. The author has an hindex of 57, co-authored 142 publications receiving 14123 citations. Previous affiliations of Christopher C.W. Hughes include Memorial Sloan Kettering Cancer Center & University of Cambridge.
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Journal ArticleDOI
Of mice and not men: differences between mouse and human immunology
TL;DR: Known discrepancies in both innate and adaptive immunity are outlined, including balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets andChemokine and chemokine receptor expression.
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CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.
Karin Karmann,Christopher C.W. Hughes,Jeffrey S. Schechner,William C. Fanslow,Jordan S. Pober +4 more
TL;DR: It is concluded that endothelial CD40 may play a role as a signaling receptor in the development of T-cell-mediated inflammatory reactions.
Journal ArticleDOI
Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.
Martin N. Nakatsu,Richard C.A. Sainson,Jason Aoto,Kevin L. Taylor,Mark Aitkenhead,Sofía Pérez-del-Pulgar,Philip M. Carpenter,Christopher C.W. Hughes +7 more
TL;DR: This improved model recapitulates all the major steps of angiogenesis seen in vivo and provides a powerful model for analysis of this complex phenomenon.
Journal ArticleDOI
A conserved mechanism for steroid receptor translocation to the plasma membrane.
Ali Pedram,Mahnaz Razandi,Richard C.A. Sainson,Jin Kyung Kim,Christopher C.W. Hughes,Ellis R. Levin +5 more
TL;DR: A highly conserved 9 amino acid motif in the ligand binding domains (E domains) of human/mouse ERα and ERβ, progesterone receptors A and B, and the androgen receptor is identified, which facilitated caveolin-1 association, subsequent membrane localization, and steroid signaling.
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Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska,Kari Alitalo,Elizabeth Allen,Andrey Anisimov,Alfred C. Aplin,Robert Auerbach,Hellmut G. Augustin,Hellmut G. Augustin,David O. Bates,Judy R. van Beijnum,R. Hugh F. Bender,Gabriele Bergers,Gabriele Bergers,Andreas Bikfalvi,Joyce Bischoff,Barbara C. Böck,Barbara C. Böck,Peter C. Brooks,Federico Bussolino,Bertan Cakir,Peter Carmeliet,Daniel Castranova,Anca Maria Cimpean,Ondine Cleaver,George Coukos,George E. Davis,Michele De Palma,Anna Dimberg,Ruud P.M. Dings,Valentin Djonov,Andrew C. Dudley,Neil Dufton,Sarah-Maria Fendt,Napoleone Ferrara,Marcus Fruttiger,Dai Fukumura,Bart Ghesquière,Bart Ghesquière,Yan Gong,Robert J. Griffin,Adrian L. Harris,Christopher C.W. Hughes,Nan W. Hultgren,M. Luisa Iruela-Arispe,Melita Irving,Rakesh K. Jain,Raghu Kalluri,Joanna Kalucka,Robert S. Kerbel,Jan Kitajewski,Ingeborg Klaassen,Hynda K. Kleinmann,Pieter Koolwijk,Elisabeth Kuczynski,Brenda R. Kwak,Koen Marien,Juan M. Melero-Martin,Lance L. Munn,Roberto F. Nicosia,Agnès Noël,Jussi Nurro,Anna-Karin Olsson,Tatiana V. Petrova,Kristian Pietras,Roberto Pili,Jeffrey W. Pollard,Mark J. Post,Paul H.A. Quax,Gabriel A. Rabinovich,Marius Raica,Anna M. Randi,Domenico Ribatti,Curzio Rüegg,Reinier O. Schlingemann,Reinier O. Schlingemann,Stefan Schulte-Merker,Lois E.H. Smith,Jonathan W. Song,Steven A. Stacker,Jimmy Stalin,Amber N. Stratman,Maureen Van de Velde,Victor W.M. van Hinsbergh,Peter B. Vermeulen,Johannes Waltenberger,Brant M. Weinstein,Hong Xin,Bahar Yetkin-Arik,Seppo Ylä-Herttuala,Mervin C. Yoder,Arjan W. Griffioen +90 more
TL;DR: In vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis are described and critical aspects that are relevant for their execution and proper interpretation are highlighted.