A
Ann Kalita
Researcher at McGill University
Publications - 4
Citations - 1693
Ann Kalita is an academic researcher from McGill University. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 3, co-authored 4 publications receiving 1667 citations. Previous affiliations of Ann Kalita include International Centre for Genetic Engineering and Biotechnology.
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Journal ArticleDOI
Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.
Alan Storey,Miranda Thomas,Ann Kalita,Catherine A. Harwood,Daniela Gardiol,Fiamma Mantovani,Judith Breuer,Irene M. Leigh,Greg Matlashewski,Lawrence Banks +9 more
TL;DR: Allelic analysis of patients with HPV-associated tumours revealed a striking overrepresentation of homozygous arginine-72 p53 compared with the normal population, which indicated that individuals homozygously for arginin 72 are about seven times more susceptible to HPV- associated tumorigenesis than heterozygotes.
Journal ArticleDOI
Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically
TL;DR: Both p53Arg and p53Pro are morphologically wild type and do not differ in their ability to bind to DNA in a sequence-specific manner, however, there are a number of differences between the p53 variants in their abilities to bind components of the transcriptional machinery, to activate transcription, to induce apoptosis, and to repress the transformation of primary cells.
Journal ArticleDOI
p53 polymorphism and risk of cervical cancer
Alan Storey,Miranda Thomas,Ann Kalita,Catherine A. Harwood,Daniela Gardiol,Fiamma Mantovani,Judith Breuer,Irene M. Leigh,Greg Matlashewski,Lawrence Banks +9 more
TL;DR: It is concluded that homozygous p53Arg is not a risk factor for cancer associated with human papilloma virus (HPV) and investigations should be extended to different populations, and it is encouraged that such studies are underway.