C
Catherine A. Harwood
Researcher at Queen Mary University of London
Publications - 252
Citations - 11257
Catherine A. Harwood is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Medicine & Skin cancer. The author has an hindex of 51, co-authored 204 publications receiving 9817 citations. Previous affiliations of Catherine A. Harwood include National Cancer Research Institute & University of London.
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Journal ArticleDOI
Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.
Alan Storey,Miranda Thomas,Ann Kalita,Catherine A. Harwood,Daniela Gardiol,Fiamma Mantovani,Judith Breuer,Irene M. Leigh,Greg Matlashewski,Lawrence Banks +9 more
TL;DR: Allelic analysis of patients with HPV-associated tumours revealed a striking overrepresentation of homozygous arginine-72 p53 compared with the normal population, which indicated that individuals homozygously for arginin 72 are about seven times more susceptible to HPV- associated tumorigenesis than heterozygotes.
Journal ArticleDOI
Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage
Peter O'Donovan,C. M. Perrett,Xiaohong Zhang,Beatriz Montaner,Yao-Zhong Xu,Catherine A. Harwood,Jane M. McGregor,Susan L. Walker,Fumio Hanaoka,Peter Karran +9 more
TL;DR: It is demonstrated that biologically relevant doses of ultraviolet A (UVA) generate ROS in cultured cells with 6- TG–substituted DNA and that 6-TG and UVA are synergistically mutagenic.
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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
Maria C. Marin,Christine A. Jost,Louise Brooks,Meredith S. Irwin,Jenny O'Nions,John Tidy,Nicholas D. James,Jane M. McGregor,Catherine A. Harwood,Isik G. Yulug,Karen H. Vousden,Martin J. Allday,Barry A. Gusterson,Shuntaro Ikawa,Philip W. Hinds,Tim Crook,William G. Kaelin +16 more
TL;DR: It is reported that some tumour-derived p53 mutants can bind to and inactivate p73, and it is found that the Arg-containing allele was preferentially mutated and retained in squamous cell tumours arising in Arg/Pro germline heterozygotes.
Journal ArticleDOI
Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals.
Catherine A. Harwood,T. Surentheran,Jane M. McGregor,Patricia J. Spink,Irene M. Leigh,Judith Breuer,Charlotte M. Proby +6 more
TL;DR: Evidence is provided that the prevalence and spectrum of HPV types does not differ in squamous cell carcinomas, basalcell carcinomas or premalignancies within the two populations, which has important implications for future investigation of the role of HPV in cutaneous carcinogenesis at a functional level.
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Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
TL;DR: Evidence is presented that Bak protein is involved in signaling apoptosis in the skin in response to UVB damage, and that cutaneous HPV E6 proteins target and abrogate Bak function by promoting its proteolytic degradation both in vitro and in regenerated epithelium.