Anna Aulicino

TL;DR: Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.

TL;DR: An unbiased atlas of human colonic CD8+ T cell phenotypes in health and ulcerative colitis is compiled using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry to identify and characterize terminally differentiated dysfunctional UC CD8 + T cells expressing IL-26.

TL;DR: Results provide evidence that components abundant in mycobacterial cell wall are able to interact with NKp44 (AG, MA) and TLR‐2 (PG), respectively, and promote activation of resting NK cells and IFN‐γ production, and could play a secondary role in maintaining cell activation.

TL;DR: The characterization of two M. tuberculosis conditional mutant strains confirmed that the repression of eccB5-eccC5 genes is detrimental for growth of M.culosis both in vitro and in THP-1 human macrophage cell line, and revealed that both EccB5 and EccC5 are required for secretion of ESX-5 specific substrates, thus confirming that they are indeed components of the ESX -5 secretion machinery.

TL;DR: Two important human pathogens, Salmonella and Clostridia, are focused on; they exemplify how a bacterial pathogen must navigate and exploit this web of iron homeostasis interactions to avoid host nutritional immunity and replicate successfully.