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Benedikt M. Kessler
Researcher at University of Oxford
Publications - 421
Citations - 29263
Benedikt M. Kessler is an academic researcher from University of Oxford. The author has contributed to research in topics: Ubiquitin & Biology. The author has an hindex of 82, co-authored 385 publications receiving 24243 citations. Previous affiliations of Benedikt M. Kessler include Leiden University & National University of Malaysia.
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Journal ArticleDOI
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Haim Y. Cohen,Christine M. Miller,Kevin J. Bitterman,Nathan R. Wall,Brian G Hekking,Benedikt M. Kessler,Konrad T. Howitz,Myriam Gorospe,Rafael de Cabo,David A. Sinclair +9 more
TL;DR: It is shown that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals, suggesting that CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells.
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Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Yanchun Peng,Alexander J. Mentzer,G Liu,G Liu,X Yao,Z Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,C Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,Guido C. Paesen,Jonathan M. Grimes,Alfred A. Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,B Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,P Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,J K Baillie,Shona C Moore,Openshaw Pjm.,M A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,G Kerr,Philip J. R. Goulder,T Lockett,R Levin,Y Zhang,Y Zhang,R Jing,Ho L-P.,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Gavin R. Screaton,Juthathip Mongkolsapaya,Andrew J. McMichael,Julian C. Knight,Graham S. Ogg,Tao Dong +67 more
TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L. Mills,Dylan G. Ryan,Hiran A. Prag,Dina Dikovskaya,Deepthi Menon,Zbigniew Zaslona,Mark P. Jedrychowski,Ana S. H. Costa,Maureen Higgins,Emily Hams,John Szpyt,Marah C. Runtsch,Martin S. King,Joanna F. McGouran,Roman Fischer,Benedikt M. Kessler,Anne F. McGettrick,Mark M. Hughes,Richard G. Carroll,Richard G. Carroll,Lee M. Booty,Lee M. Booty,Elena V. Knatko,Paul J. Meakin,Michael L.J. Ashford,Louise K. Modis,Gino Brunori,Daniel C. Sévin,Padraic G. Fallon,Stuart T. Caldwell,Edmund R.S. Kunji,Edward T. Chouchani,Christian Frezza,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova,Richard C. Hartley,Michael P. Murphy,Luke A. J. O'Neill,Luke A. J. O'Neill +38 more
TL;DR: It is shown that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 by lipopolysaccharide in mouse and human macrophages and that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconates production.
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Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
Neil P. Blackledge,Anca M. Farcas,Takashi Kondo,Hamish W King,Joanna F. McGouran,Lars L. P. Hanssen,Shinsuke Ito,Sarah Cooper,Kaori Kondo,Yoko Koseki,Tomoyuki Ishikura,Hannah K. Long,Thomas W. Sheahan,Neil Brockdorff,Benedikt M. Kessler,Haruhiko Koseki,Robert J. Klose +16 more
TL;DR: Using a de novo targeting assay in mouse embryonic stem cells, it is found that PRC1-dependent H2AK119ub1 leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain, providing a surprising PRC 1-dependent logic forPRC2 occupancy at target sites in vivo.
Journal ArticleDOI
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Haim Y. Cohen,Siva Lavu,Kevin J. Bitterman,Brian G Hekking,Thomas A Imahiyerobo,Christine M. Miller,Roy A. Frye,Hidde L. Ploegh,Benedikt M. Kessler,David A. Sinclair +9 more
TL;DR: It is demonstrated that increased acetylation of Ku70 disrupts the Ku70-Bax interaction and coincides with cytoplasmic accumulation of CBP and PCAF, shedding light on the role of acetyltransferases as tumor suppressors.