T
Tarun Gupta
Researcher at John Radcliffe Hospital
Publications - 5
Citations - 388
Tarun Gupta is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Colitis & CD8. The author has an hindex of 4, co-authored 5 publications receiving 99 citations. Previous affiliations of Tarun Gupta include Medical Research Council.
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Journal ArticleDOI
Spatiotemporal analysis of human intestinal development at single-cell resolution
David Fawkner-Corbett,Agne Antanaviciute,Kaushal Parikh,Marta Jagielowicz,Marta Jagielowicz,A S Gerós,A S Gerós,Tarun Gupta,Tarun Gupta,Neil Ashley,Doran Khamis,Darren J. Fowler,Edward Morrissey,C Cunningham,Johnson Prv.,Hashem Koohy,Hashem Koohy,Alison Simmons,Alison Simmons +18 more
TL;DR: In this paper, single-cell RNA sequencing and spatial transcriptomics were used to characterize intestinal morphogenesis through time and identify 101 cell states including epithelial and mesenchymal progenitor populations and programs linked to key morphogenetic milestones.
Journal ArticleDOI
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
Daniele Corridoni,Daniele Corridoni,Agne Antanaviciute,Agne Antanaviciute,Tarun Gupta,Tarun Gupta,David Fawkner-Corbett,David Fawkner-Corbett,Anna Aulicino,Anna Aulicino,Marta Jagielowicz,Marta Jagielowicz,Kaushal Parikh,Kaushal Parikh,Emmanouela Repapi,Steve Taylor,Dai Ishikawa,Ryo Hatano,Taketo Yamada,Wei Xin,Hubert Slawinski,Rory Bowden,Giorgio Napolitani,Oliver Brain,Chikao Morimoto,Hashem Koohy,Hashem Koohy,Alison Simmons,Alison Simmons +28 more
TL;DR: An unbiased atlas of human colonic CD8+ T cell phenotypes in health and ulcerative colitis is compiled using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry to identify and characterize terminally differentiated dysfunctional UC CD8 + T cells expressing IL-26.
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Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis.
Sarah C. Sasson,Sarah C. Sasson,Stephanie Slevin,Stephanie Slevin,Vincent Cheung,Vincent Cheung,Isar Nassiri,Anna Olsson-Brown,Anna Olsson-Brown,Eve Fryer,Ricardo C. Ferreira,Dominik Trzupek,Tarun Gupta,Lulia Al-Hillawi,Lulia Al-Hillawi,Mari-lenna Issaias,Alistair Easton,Leticia Campo,Michael Fitzpatrick,Michael Fitzpatrick,Joss Adams,Meenali Chitnis,Andrew Protheroe,Mark Tuthill,Nicholas Coupe,Alison Simmons,Miranda Payne,Mark R. Middleton,Mark R. Middleton,Simon Travis,Simon Travis,Benjamin P. Fairfax,Benjamin P. Fairfax,Paul Klenerman,Paul Klenerman,Oliver Brain,Oliver Brain +36 more
TL;DR: In this article, the authors identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential novel therapeutic targets.
Journal ArticleDOI
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Cheung Vtf.,Tarun Gupta,Anna Olsson-Brown,Sreedhar Subramanian,Sarah C. Sasson,Jonathan Heseltine,Eve Fryer,Elena Collantes,Joseph J. Sacco,Joseph J. Sacco,Munir Pirmohamed,Alison Simmons,Paul Klenerman,Mark Tuthill,A S Protheroe,Meenali Chitnis,Benjamin P. Fairfax,Benjamin P. Fairfax,Miranda Payne,Miranda Payne,Mark R. Middleton,Mark R. Middleton,Oliver Brain +22 more
TL;DR: The data support utilising endoscopic scoring for patients with >grade 1 CTCAE disease, and demonstrate the potential prognostic utility of objective histologic scoring.
Journal ArticleDOI
Aortic valve area using computed tomography‐derived correction factor to improve the validity of left ventricular outflow tract measurements
TL;DR: This study aimed to improve the accuracy of transthoracic echocardiography‐based aortic valve area (AVA) calculation using continuity equation (CE) by introducing a correction factor (CF) derived from multidetector computed tomography angiography (MDCTA) images and validate it in aortIC stenosis (AS) patients.