A
Anna Aviñó
Researcher at Spanish National Research Council
Publications - 124
Citations - 2124
Anna Aviñó is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Oligonucleotide & DNA. The author has an hindex of 24, co-authored 117 publications receiving 1830 citations. Previous affiliations of Anna Aviñó include University of Barcelona.
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Fundamental aspects of the nucleic acid i-motif structures
TL;DR: The present work provides an overall picture of the i-motif structure and special attention has been made to the i -motif structures that could have a hypothetical role in vivo, such as those present near the promoter region of several oncogenes.
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Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications
TL;DR: The impact of modified nucleosides and non-natural backbones in the guanine tetrads or in the loops and the introduction of pendant groups at the 3' or 5'-ends are described.
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An aptamer-gated silica mesoporous material for thrombin detection
Mar Oroval,Estela Climent,Carmen Coll,Ramon Eritja,Anna Aviñó,María D. Marcos,Félix Sancenón,Ramón Martínez-Máñez,Pedro Amorós +8 more
TL;DR: An aptamer-capped mesoporous material for the selective and sensitive detection of α-thrombin in human plasma and serum has been prepared and characterised.
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Selective depletion of metastatic stem cells as therapy for human colorectal cancer
María Virtudes Céspedes,Ugutz Unzueta,Anna Aviñó,Alberto Gallardo,Patricia Álamo,Rita Sala,Alejandro Sánchez-Chardi,Isolda Casanova,Maria Antonia Mangues,Antonio Lopez-Pousa,Ramon Eritja,Antonio Villaverde,Esther Vázquez,Ramon Mangues +13 more
TL;DR: This targeted drug delivery approach yields potent antimetastatic effect, through selective depletion of metastatic CXCR4+ cancer cells, and validates metastatic stem cells (MetSCs) as targets for clinical therapy.
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Stepwise solid-phase synthesis of oligonucleotide-peptide hybrids
Beatriz G. de la Torre,Anna Aviñó,Gemma Tarrason,Jaume Piulats,Fernando Albericio,Ramon Eritja +5 more
TL;DR: Oligonucleotide-peptide hybrids containing a nuclear transport signal have been synthesized stepwise on a polyethyleneglycol-polystyrene support using base labile protecting groups for the nucleobases and aminoacid side chains.