Anna Casati

TL;DR: In vitro assays unveil a hierarchy of immunoregulatory activity among MDSC subsets that is controlled by tumor‐released GM‐CSF, and Gene silencing experiments indicated that GM‐ CSF was necessary to induce preferential expansion of both CD11b+/Gr‐1int and CD11B+/ Gr‐1low subsets in the spleen of tumor‐bearing mice and mediate tumor‐induced tolerance.

TL;DR: Pannexin hemichannel-mediated release of ATP provides an autocrine, costimulatory signal for T cell activation as discussed by the authors, but how extracellular ATP might affect T cell function in the context of inflammation is unclear.

TL;DR: Pannexin hemichannel–mediated release of ATP provides an autocrine, costimulatory signal for T cell activation and therapeutic intervention against ATP synthesis and release may be of benefit in the treatment of T cell–mediated inflammatory diseases.

TL;DR: The notion that impaired immune tolerance and defective immune regulation are involved in the pathophysiology of OS is supported, as a knockin murine model carrying the Rag2 R229Q mutation mimicked most symptoms of human OS.

TL;DR: Risks of fatal and nonfatal cardiovascular events, diabetes mellitus, hypertension and LVH were similar for the three definitions of metabolic syndrome, however, the AHA and IDF definitions are more sensitive than that of ATPIII in identifying metabolic syndrome condition.