P
Pietro Luigi Poliani
Researcher at University of Brescia
Publications - 149
Citations - 7190
Pietro Luigi Poliani is an academic researcher from University of Brescia. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 41, co-authored 136 publications receiving 5961 citations. Previous affiliations of Pietro Luigi Poliani include Vita-Salute San Raffaele University & University of Pittsburgh.
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Journal ArticleDOI
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
Yingyue Zhou,Wilbur M. Song,Prabhakar S. Andhey,Amanda Swain,Tyler Levy,Kelly R. Miller,Pietro Luigi Poliani,Manuela Cominelli,Shikha Grover,Susan Gilfillan,Marina Cella,Tyler K. Ulland,Konstantin Zaitsev,Konstantin Zaitsev,Akinori Miyashita,Takeshi Ikeuchi,Makoto Sainouchi,Akiyoshi Kakita,David A. Bennett,Julie A. Schneider,Michael R. Nichols,Sean A. Beausoleil,Jason D. Ulrich,David M. Holtzman,Maxim N. Artyomov,Marco Colonna +25 more
TL;DR: Single-nucleus RNA sequencing in a mouse model of Aβ accumulation and postmortem brain tissue from people with Alzheimer’s disease reveals substantial species-specific differences in transcriptional signatures, but both point to the contribution of glia and the importance of TREM2.
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TREM2 sustains microglial expansion during aging and response to demyelination
Pietro Luigi Poliani,Yaming Wang,Elena Fontana,Michelle L. Robinette,Yoshinori Yamanishi,Susan Gilfillan,Marco Colonna +6 more
TL;DR: The basis for this genetic association is addressed using Trem2(-/-) mice, and it is concluded that TREM2 is required for promoting microglia expansion during aging and microglial response to insults of the white matter.
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NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
Roberta Castriconi,Antonio Daga,Alessandra Dondero,Gianluigi Zona,Pietro Luigi Poliani,Alice Melotti,Fabrizio Griffero,Daniela Marubbi,Renato Spaziante,Francesca Bellora,Lorenzo Moretta,Alessandro Moretta,Giorgio Corte,Cristina Bottino +13 more
TL;DR: All stem cell-cultured glioblastoma cells analyzed did not express protective amounts of HLA class I molecules, while expressing various ligands of activating NK receptors that triggered optimal NK cell cytotoxicity.
Journal ArticleDOI
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.
Karel Otero,Isaiah R. Turnbull,Pietro Luigi Poliani,William Vermi,Elisa Cerutti,Taiki Aoshi,Taiki Aoshi,Ilaria Tassi,Toshiyuki Takai,Samuel L. Stanley,Mark J. Miller,Andrey S. Shaw,Marco Colonna +12 more
TL;DR: DAP12 deficiency impaired the M-CSF-induced proliferation and survival of macrophages in vitro, providing a mechanistic explanation for the many defects of DAP12-deficient mononuclear phagocytes.
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Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas.
Serena Pellegatta,Pietro Luigi Poliani,Daniela Corno,Francesca Menghi,F. Ghielmetti,Blanca Suarez-Merino,Valentina Caldera,Sara Nava,Maria Ravanini,Fabio Facchetti,Maria Grazia Bruzzone,Gaetano Finocchiaro +11 more
TL;DR: It is suggested that DC targeting of CSC provides a higher level of protection against GL261 gliomas, a finding with potential implications for the design of clinical trials based on DC vaccination.