C
Circe Mesa
Researcher at Center of Molecular Immunology
Publications - 37
Citations - 2330
Circe Mesa is an academic researcher from Center of Molecular Immunology. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 18, co-authored 32 publications receiving 2061 citations.
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Journal ArticleDOI
Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
Ilaria Marigo,Erika Bosio,Samantha Solito,Circe Mesa,Audry Fernández,Luigi Dolcetti,Stefano Ugel,Nada Sonda,Silvio Bicciato,Erika Falisi,Fiorella Calabrese,Giuseppe Basso,Paola Zanovello,Emanuele Cozzi,Susanna Mandruzzato,Vincenzo Bronte +15 more
TL;DR: Adoptive transfer of tumor antigen-specific CD8(+) T lymphocytes resulted in therapy of established tumors only in mice lacking C/EBPbeta in the myeloid compartment, suggesting that C/ EBPbeta is a critical regulator of the immunosuppressive environment created by growing cancers.
Journal ArticleDOI
Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
Luigi Dolcetti,Elisa Peranzoni,Stefano Ugel,Ilaria Marigo,Audry Fernandez Gomez,Circe Mesa,Markus Geilich,Gregor Winkels,Elisabetta Traggiai,Anna Casati,Fabio Grassi,Vincenzo Bronte +11 more
TL;DR: In vitro assays unveil a hierarchy of immunoregulatory activity among MDSC subsets that is controlled by tumor‐released GM‐CSF, and Gene silencing experiments indicated that GM‐ CSF was necessary to induce preferential expansion of both CD11b+/Gr‐1int and CD11B+/ Gr‐1low subsets in the spleen of tumor‐bearing mice and mediate tumor‐induced tolerance.
Journal ArticleDOI
A Mouse IgG1 Monoclonal Antibody Specific for N-Glycolyl GM3 Ganglioside Recognized Breast and Melanoma Tumors
Adriana Carr,Ailette Mullet,Zaima Mazorra,Ana María Vázquez,Mauro Alfonso,Circe Mesa,Enrique Rengifo,Rolando Pérez,Luis E. Fernández +8 more
TL;DR: Immunohistochemical studies in fresh tumor tissues showed that 14F7 MAb strongly recognized in antigen expressed in human breast and melanoma tumors.
Journal ArticleDOI
Enhancement of the immune response to poorly immunogenic gangliosides after incorporation into very small size proteoliposomes (VSSP).
Francisco Estevez,Adriana Carr,Leobaldo Solorzano,Oscar Valiente,Circe Mesa,Osquel Barroso,Gustavo Sierra,Luis E. Fernández +7 more
TL;DR: The immunological and physicochemical properties of very small size proteoliposomes (VSSP) obtained by using anionic detergents to incorporate gangliosides into the outer membrane protein complex (OMPC) of N. meningitidis are reported.
Journal ArticleDOI
Challenges facing adjuvants for cancer immunotherapy.
Circe Mesa,Luis E. Fernández +1 more
TL;DR: The present review discusses the role of cancer adjuvants at the different phases of the generation of antitumour immunity following vaccination.