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Brigitte Lemercier
Researcher at Pasteur Institute
Publications - 28
Citations - 1697
Brigitte Lemercier is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Proinflammatory cytokine & T-cell receptor. The author has an hindex of 21, co-authored 28 publications receiving 1563 citations.
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Journal ArticleDOI
Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response
Natacha Colliou,Damien Picard,Frédérique Caillot,Sébastien Calbo,Stéphanie Le Corre,Annick Lim,Brigitte Lemercier,Brigitte Le Mauff,Maud Maho-Vaillant,Serge Jacquot,Christophe Bedane,Philippe Bernard,Frédéric Caux,Catherine Prost,Emmanuel Delaporte,Marie-Sylvie Doutre,Brigitte Dréno,Nathalie Franck,Saskia Ingen-Housz-Oro,Olivier Chosidow,Christine Pauwels,Catherine Picard,Jean-Claude Roujeau,M.-L. Sigal,E. Tancrede-Bohin,Isabelle Templier,Rüdiger Eming,Michael Hertl,Michel D'Incan,Pascal Joly,Philippe Musette +30 more
TL;DR: It is found that rituximab therapy can help pemphigus patients even after 6 years, in part by reshaping the B cell repertoire during reconstitution, allowing for long-term effects in addition to the short-term loss of pathogenic B cells.
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Staphylococcal Enterotoxin-Like Toxins U2 and V, Two New Staphylococcal Superantigens Arising from Recombination within the Enterotoxin Gene Cluster
Damien Thomas,Sophie Jarraud,Brigitte Lemercier,Grégoire Cozon,Klara Echasserieau,Jerome Etienne,Marie-Lise Gougeon,Gerard Lina,François Vandenesch +8 more
TL;DR: Data show that egc is indeed capable of generating new superantigen genes through recombination, and one strain with an atypical egc locus produced two new enterotoxins, designated SElV and SElU2, generated by recombination between selm and sei, producing selv.
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Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels.
Benedetta Belloni,Mahzad Ziai,Annick Lim,Brigitte Lemercier,M. Sbornik,Stephan Weidinger,Christian Andres,Christina Schnopp,Johannes Ring,Rüdiger Hein,Markus Ollert,Martin Mempel +11 more
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A Mycoplasma fermentans-derived Synthetic Lipopeptide Induces AP-1 and NF-κB Activity and Cytokine Secretion in Macrophages via the Activation of Mitogen-activated Protein Kinase Pathways
TL;DR: The findings demonstrate that the synthetic analog of MALP-2 reproduces the macrophage stimulation activity found in different fractions of mycoplasmas and constitutes a valuable surrogate for investigating immunomodulation by these microorganisms and evaluating the role that this activity plays in the development of inflammatory diseases associated with myCoplasma infections.
Journal ArticleDOI
B-Cell Depletion Immunotherapy in Pemphigus: Effects on Cellular and Humoral Immune Responses
Hugo Mouquet,Philippe Musette,Marie-Lyse Gougeon,Serge Jacquot,Brigitte Lemercier,Annick Lim,Danièle Gilbert,Ingrid Dutot,Jean C. Roujeau,Michel D'Incan,Christophe Bedane,François Tron,Pascal Joly +12 more
TL;DR: The depletion of autoreactive B cells leading to the elimination of anti-Dsg autoantibodies in most remitted patients and the restoration of a diverse B-cell repertoire by naive B lymphocytes may provide an explanation for the long-lasting efficacy of rituximab in pemphigus patients.