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Anna Collén
Researcher at AstraZeneca
Publications - 22
Citations - 820
Anna Collén is an academic researcher from AstraZeneca. The author has contributed to research in topics: Trichoderma reesei & Medicine. The author has an hindex of 12, co-authored 16 publications receiving 647 citations. Previous affiliations of Anna Collén include Lund University.
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Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes.
Luisa Statello,Marco Maugeri,Elena Garre,Muhammad Nawaz,Jessica Wahlgren,Alexandros Papadimitriou,Christina Lundqvist,Lennart Lindfors,Anna Collén,Per Sunnerhagen,Marco Ragusa,Michele Purrello,Cinzia Di Pietro,Natalie J. Tigue,Hadi Valadi +14 more
TL;DR: The data indicate that RNA binding proteins (RBPs) could end up in exosomes together with RNA molecules in the form of RNA–ribonucleoprotein complexes, which could be important for the transport of RNAs into exosome and the maintenance ofRNAs inside exosomal-RNA species.
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Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.
Li-Ming Gan,Li-Ming Gan,Li-Ming Gan,Maria Lagerström-Fermér,Leif Carlsson,Cecilia Arfvidsson,Ann-Charlotte Egnell,Anna Rudvik,M Kjaer,Anna Collén,James D. Thompson,John L. Joyal,Ligia Chialda,Thomas Koernicke,Rainard Fuhr,Kenneth R. Chien,Regina Fritsche-Danielson +16 more
TL;DR: It is shown in a phase 1 clinical trial that a modified mRNA encoding VEGF-A is well tolerated in patients with type 2 diabetes and may have therapeutic potential for regenerative angiogenesis.
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A cellulose-binding module of the Trichoderma reesei β-mannanase Man5A increases the mannan-hydrolysis of complex substrates
TL;DR: Binding experiments using activity detection of Man5A and Man5ADeltaCBM suggests that the CBM binds to cellulose but not to mannan, which is closely associated with cellulose in plant cell walls.
Journal ArticleDOI
Large-scale separation and production of engineered proteins, designed for facilitated recovery in detergent-based aqueous two-phase extraction systems
Klaus Selber,Folke Tjerneld,Anna Collén,Teppo Hyytiä,Tiina Nakari-Setälä,Michael Bailey,Richard Fagerström,John Kan,Joop van der Laan,Merja Penttilä,M.-R. Kula +10 more
TL;DR: The decreased separation efficiency appears to be correlated with changes in glycosylation at lower cultivation temperatures (Less) and the large-scale production of a fusion protein EGIcore-HFBI was chosen.
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A novel two-step extraction method with detergent/polymer systems for primary recovery of the fusion protein endoglucanase I–hydrophobin I
Anna Collén,Josefine Persson,Markus Linder,Tiina Nakari-Setälä,Merja Penttilä,Folke Tjerneld,Ulf Sivars +6 more
TL;DR: The addition of thermoseparating co-polymer is a novel approach to remove detergent and effectively releases the fusion protein EGI(core)-HFBI into a water phase.