Anna Demartis

TL;DR: It is reported here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in mouse hypothalamic nuclei involved in the regulation of energy balance.

TL;DR: The demonstration of functionally independent receptor binding sites on IL‐6 suggests that it could be possible to design super‐antagonists of other helical cytokines which drive the assembly of structurally related multisubunit receptor complexes.

TL;DR: The level of trans‐activation observed with the natural promoter containing both HNF‐1 binding sites is far greater than the level of mutated variants containing only one of the two sites, which strongly suggests that two H NF‐1 molecules bound simultaneously to sites distant from each other can act synergistically to activate gene expression.

TL;DR: Results demonstrate that gene electrotransfer can be applied to produce therapeutically significant levels of erythropoietin in chronic renal failure.

TL;DR: IL-6 receptor antagonists are pro-apoptotic factors for the IL-6-dependent human myeloma cell line XG-1 and their capacity to induce cell death is in direct relation to their affinity for IL- 6R alpha, degree of gp130 binding impairment, and efficiency to inhibit intracellular signaling events.