G
Giacomo Paonessa
Researcher at Merck & Co.
Publications - 63
Citations - 4065
Giacomo Paonessa is an academic researcher from Merck & Co.. The author has contributed to research in topics: Glycoprotein 130 & Hepatitis C virus. The author has an hindex of 29, co-authored 61 publications receiving 3957 citations. Previous affiliations of Giacomo Paonessa include Turku University Hospital & Schering-Plough.
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Journal ArticleDOI
Specific recognition of cruciform DNA by nuclear protein HMG1.
TL;DR: Biochemical and immunological data showed that this protein is HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus, which points to a critical role for cruciform DNA conformations.
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Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
Giacomo Paonessa,Rita Graziani,A De Serio,R. Savino,Laura Ciapponi,Armin Lahm,Anna Laura Salvati,Carlo Toniatti,Gennaro Ciliberto +8 more
TL;DR: It is demonstrated here that both the site 2 and site 3 IL‐ 6 variants complexed with IL‐6R alpha bind a single gp130 molecule but are unable to dimerize it, whereas the combined site 2/3 variants lose the ability to interact with gp130.
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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
Isabelle Gloaguen,Patrizia Costa,Anna Demartis,Domenico Lazzaro,Annalise Di Marco,Rita Graziani,Giacomo Paonessa,Fang Chen,Charles Rosenblum,Lex H.T. Van der Ploeg,Riccardo Cortese,Gennaro Ciliberto,Ralph Laufer +12 more
TL;DR: It is reported here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in mouse hypothalamic nuclei involved in the regulation of energy balance.
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Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region.
M.G. Persico,G. Viglietto,G. Martini,Daniela Toniolo,Giacomo Paonessa,C Moscatelli,R. Dono,Tom Vulliamy,Lucio Luzzatto,Michele D'Urso +9 more
TL;DR: The isolation of cDNA clones from HeLa cells, SV40-transformed human fibroblasts, human placenta and human teratocarcinoma cell lines have enabled us to sequence the entire coding region of Gd, providing the entire amino acid sequence of human G6PD for the first time.
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Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA.
TL;DR: Northern analysis reveals several mRNA species present in different combinations in various rat tissues, most likely located within the first 250 amino acids, is highly homologous to the sequence of CTF/NF1 purified from HeLa cells.