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Sergey G. Kuznetsov
Researcher at University of Helsinki
Publications - 62
Citations - 2389
Sergey G. Kuznetsov is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Homologous recombination. The author has an hindex of 19, co-authored 41 publications receiving 2145 citations. Previous affiliations of Sergey G. Kuznetsov include University of Kiel & I.M. Sechenov First Moscow State Medical University.
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Journal ArticleDOI
Recombineering: a homologous recombination-based method of genetic engineering
TL;DR: Recombineering is an efficient method of in vivo genetic engineering applicable to chromosomal as well as episomal replicons in Escherichia coli that circumvents the need for most standard in vitro cloning techniques.
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A handcuff model for the cohesin complex
Nenggang Zhang,Sergey G. Kuznetsov,Shyam K. Sharan,Kaiyi Li,Pulivarthi H. Rao,Debananda Pati +5 more
TL;DR: Results show that three of the four human cohesin core subunits (Smc1, Smc3, and Rad21) interact with themselves in an Scc3 (SA1/SA2)-dependent manner, which support a two-ring handcuff model for the cohesIn complex, which is flexible enough to establish and maintain sister chromatid cohesion as well as ensure the fidelity of chromosome segregation in higher eukaryotes.
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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
Jutta Zimmer,Eliana M.C. Tacconi,Cecilia Folio,Sophie Badie,Manuela Porru,Kerstin Klare,Manuela Tumiati,Enni Markkanen,Swagata Halder,Anderson J. Ryan,Stephen P. Jackson,Stephen P. Jackson,Kristijan Ramadan,Sergey G. Kuznetsov,Annamaria Biroccio,Julian E. Sale,Madalena Tarsounas +16 more
TL;DR: It is demonstrated that the replication efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells lacking HR, highlighting the therapeutic potential of G4-stabilizing drugs to selectively eliminate HR-compromised cells and tumors, including those resistant to PARP inhibition.
Journal ArticleDOI
pHLIP peptide targets nanogold particles to tumors
Lan Yao,Jennifer Daniels,Anna Moshnikova,Sergey G. Kuznetsov,Aftab Ahmed,Donald M. Engelman,Yana K. Reshetnyak,Oleg A. Andreev +7 more
TL;DR: In this article, a method for the preferential targeting of gold nanoparticles to a tumor in a mouse model is described, which is based on the use of the pH Low Insertion Peptide (pHLIP), which targets various imaging agents to acidic tumors.
Journal ArticleDOI
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
Sergey G. Kuznetsov,Manuela Pellegrini,Kristy Shuda,Oscar Fernandez-Capetillo,Yilun Liu,Betty K. Martin,Sandra Burkett,Eileen Southon,Debananda Pati,Lino Tessarollo,Stephen C. West,Peter J. Donovan,André Nussenzweig,Shyam K. Sharan +13 more
TL;DR: Based on the marked reduction in Holliday junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, it is proposed that this late function may be associated with HJ resolution.