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Benjamin Stieglitz
Researcher at Queen Mary University of London
Publications - 18
Citations - 1826
Benjamin Stieglitz is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 11, co-authored 16 publications receiving 1588 citations. Previous affiliations of Benjamin Stieglitz include Francis Crick Institute & Medical Research Council.
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Journal ArticleDOI
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Fumiyo Ikeda,Yonathan Lissanu Deribe,Sigrid S. Skånland,Benjamin Stieglitz,Caroline Grabbe,Caroline Grabbe,Mirita Franz-Wachtel,Sjoerd J L van Wijk,Panchali Goswami,Vanja Nagy,Janoš Terzić,Fuminori Tokunaga,Ariadne Androulidaki,Tomoko Nakagawa,Manolis Pasparakis,Kazuhiro Iwai,John P. Sundberg,Liliana Schaefer,Katrin Rittinger,Boris Macek,Ivan Dikic,Ivan Dikic +21 more
TL;DR: It is reported that SHARPIN functions as a novel component of the linear ubiquitin chain assembly complex (LUBAC) and that the absence of SHARPin causes dysregulation of NF-κB and apoptotic signalling pathways, explaining the severe phenotypes displayed by chronic proliferative dermatitis (cpdm) in SHARPIn-deficient mice.
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An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
Christoph Wilhelm,Keiji Hirota,Benjamin Stieglitz,Jacques Van Snick,Mauro Tolaini,Katharina Lahl,Tim Sparwasser,Helena Helmby,Brigitta Stockinger +8 more
TL;DR: It was found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs) and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-8 and type 2 helper T cell cytokines and responses.
Journal ArticleDOI
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
Benjamin Stieglitz,Aylin C. Morris-Davies,Marios G. Koliopoulos,Evangelos Christodoulou,Katrin Rittinger +4 more
TL;DR: It is shown that the RING‐in‐between‐RING (RBR)‐containing region of HOIP—the catalytic subunit of LUBAC—is sufficient to generate linear ubiquitin chains, supporting the notion that RBR ligases act as RING/HECT hybrids.
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Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP
Benjamin Stieglitz,Rohini R. Rana,Marios G. Koliopoulos,Aylin C. Morris-Davies,Veronique Schaeffer,Evangelos Christodoulou,Steven Howell,N.R. Brown,Ivan Dikic,Katrin Rittinger +9 more
TL;DR: The crystal structure of the catalytic core of HOIP, which belongs to the RBR (RING-between-RING) family of E3 ligases, is reported, providing a unique snapshot of the ubiquitin transfer complex containing both donor and acceptor ubiquitIn.
Journal ArticleDOI
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
Benjamin Stieglitz,Christine Bee,Daniel Schwarz,Özkan Yildiz,Anna Moshnikova,Andrei Khokhlatchev,Christian Herrmann +6 more
TL;DR: The crystal structure of Ras in complex with the Ras binding domain (RBD) of NORE1A/RAPL is described and it is demonstrated that the enlarged interface provides a rationale for an exceptionally long lifetime of the complex.