Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Schiff bases and their metal complexes as urease inhibitors - A brief review.

Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents

Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one.

Discovery of a new class of antiviral compounds: camphor imine derivatives.

An insight into synthetic Schiff bases revealing antiproliferative activities in vitro.

People are most often exposed to mercury in water, amalgam dental fillings, vaccines with ethylmercury as a preservative and in methylmercury containing fish. Foetuses and children are most susceptible to toxic mercury, which passes to their organisms through the placenta or with mother’s milk. Distribution of mercury in organs depends on the type of compound absorbed and duration of exposure. Mercury is mainly absorbed through the respiratory system. There are two types of mercury poisoning: acute and chronic. The critical organs for acute poisoning with mercury vapour are the lungs. Acute poisoning develops when large amounts of mercury are inhaled, which may lead to acute bronchitis, bronchiolitis and pneumonia. Chronic exposure to mercury vapour primarily affects the central nervous system. Mercury is considered as a contributing factor in aetiology of numerous disorders, including neurologic, renal, immunological, cardiologic, reproductive or even genetic abnormalities. Studies have demonstrated the correlation between mercury toxicity and pathogenesis of Alzheimer’s or Parkinson’s disease, autism and multiple sclerosis. Mercury may be involved in four processes which lead to genotoxicity: generation of free radicals and oxidative stress, effects on microtubules and on DNA repair mechanisms as well as direct interaction with DNA molecules.

/pdf/mercury-in-medicine-and-health-service-my15rian3k.pdf

Mercury in medicine and health service

Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2). Microtubules also serve as docking sites for periodically distributed multiprotein ciliary complexes. Radial spokes, the T-shaped ciliary complexes, repeat along the outer doublets as triplets and transduce the regulatory signals from the cilium center to the outer doublet-docked dynein arms. Using the genetic, proteomic, and microscopic approaches, we have shown that lack of Tetrahymena Cfap91 protein affects stable docking/positioning of the radial spoke RS3 and the base of RS2, and adjacent inner dynein arms, possibly due to the ability of Cfap91 to interact with a molecular ruler protein, Ccdc39. The localization studies confirmed that the level of RS3-specific proteins, Cfap61 and Cfap251, as well as RS2-associated Cfap206, are significantly diminished in Tetrahymena CFAP91-KO cells. Cilia of Tetrahymena cells with knocked-out CFAP91 beat in an uncoordinated manner and their beating frequency is dramatically reduced. Consequently, CFAP91-KO cells swam about a hundred times slower than wild-type cells. We concluded that Tetrahymena Cfap91 localizes at the base of radial spokes RS2 and RS3 and likely plays a role in the radial spoke(s) positioning and stability.

/pdf/cfap91-dependent-stability-of-the-rs2-and-rs3-base-proteins-e0yoke1o.pdf

Anna Osinka

Papers

An insight into synthetic Schiff bases revealing antiproliferative activities in vitro.

Mercury in medicine and health service

Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia