Małgorzata Sztanke

TL;DR: This work has focussed its attention on the collected synthetic simple Schiff bases of aldimine- and ketIMine-types revealing anticancer activities in vitro, that have been described in the scientific literature during the last decade, and on structural variations whose affect the antiproliferative activity in sets of the designed molecules.

TL;DR: Hydrazide 14 has exhibited remarkable inhibitory effect against SiHa and LS180 tumour cells, and simultaneously was found to be non-toxic towards the human normal cell line-HSF cells, suggesting that these derivatives have antiproliferative activities.

TL;DR: Heterobicycles of the 3e, 3g and 3j type was screened for their antiviral activities against the selected viruses' DNA and RNA and was found to exhibit virucidal properties against Echo-9 virus justifying its further investigation as the potential antiviral agent.

TL;DR: Imidazotriazinone 12, revealing remarkable dose-dependent viability decreases in human myeloma RPMI 8226 cells, was found to be completely non-toxic towards normal HSF cells and heterobicycles 8-12 were proved to exhibit significant antimetastatic potentials in the motility assay.

TL;DR: Several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD as discussed by the authors, and representatives of several different groups, including natural and chemical compounds will be characterized in this dissertation.